Guanidine‐Derived Polymeric Nanoinhibitors Target the Lysosomal V‐ATPase and Activate AMPK Pathway to Ameliorate Liver Lipid Accumulation

Guanidine‐Derived Polymeric Nanoinhibitors Target the Lysosomal V‐ATPase and Activate AMPK Pathway to Ameliorate Liver Lipid Accumulation

Abstract Current research efforts in polymer and nanotechnology applications are primarily focused on cargo delivery to enhance the therapeutic index, with limited attention being paid to self‐molecularly targeted nanoparticles, which may also exhibit significant therapeutic potential. Long‐term and...

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Main Authors: Yunfei Zhao, Ke Hu, Fangliang Wang, Lulu Zhao, Yu Su, Jun Chen, Gang Zou, Liming Yang, Li Wei, Mengjiao Deng, Yunyu He, Ping Wang, Xiong Z Ruan, Yaxi Chen, Chao Yu
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
AMPK
liver lipid accumulation
lysosome
polyguanide nanoinhibitor (PGNIs)
V‐ATPase
Online Access:https://doi.org/10.1002/advs.202408906
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