Midbrain encodes sound detection behavior without auditory cortex
Hearing involves analyzing the physical attributes of sounds and integrating the results of this analysis with other sensory, cognitive, and motor variables in order to guide adaptive behavior. The auditory cortex is considered crucial for the integration of acoustic and contextual information and i...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2024-12-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/89950 |
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| author | Tai-Ying Lee Yves Weissenberger Andrew J King Johannes C Dahmen |
| author_facet | Tai-Ying Lee Yves Weissenberger Andrew J King Johannes C Dahmen |
| author_sort | Tai-Ying Lee |
| collection | DOAJ |
| description | Hearing involves analyzing the physical attributes of sounds and integrating the results of this analysis with other sensory, cognitive, and motor variables in order to guide adaptive behavior. The auditory cortex is considered crucial for the integration of acoustic and contextual information and is thought to share the resulting representations with subcortical auditory structures via its vast descending projections. By imaging cellular activity in the corticorecipient shell of the inferior colliculus of mice engaged in a sound detection task, we show that the majority of neurons encode information beyond the physical attributes of the stimulus and that the animals’ behavior can be decoded from the activity of those neurons with a high degree of accuracy. Surprisingly, this was also the case in mice in which auditory cortical input to the midbrain had been removed by bilateral cortical lesions. This illustrates that subcortical auditory structures have access to a wealth of non-acoustic information and can, independently of the auditory cortex, carry much richer neural representations than previously thought. |
| format | Article |
| id | doaj-art-1b6bb86eeb8143e3a0c61562c1ac5a35 |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-1b6bb86eeb8143e3a0c61562c1ac5a352024-12-17T13:08:16ZengeLife Sciences Publications LtdeLife2050-084X2024-12-011210.7554/eLife.89950Midbrain encodes sound detection behavior without auditory cortexTai-Ying Lee0https://orcid.org/0000-0001-8072-1219Yves Weissenberger1Andrew J King2https://orcid.org/0000-0001-5180-7179Johannes C Dahmen3https://orcid.org/0000-0001-9889-8303Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United KingdomDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United KingdomDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United KingdomDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United KingdomHearing involves analyzing the physical attributes of sounds and integrating the results of this analysis with other sensory, cognitive, and motor variables in order to guide adaptive behavior. The auditory cortex is considered crucial for the integration of acoustic and contextual information and is thought to share the resulting representations with subcortical auditory structures via its vast descending projections. By imaging cellular activity in the corticorecipient shell of the inferior colliculus of mice engaged in a sound detection task, we show that the majority of neurons encode information beyond the physical attributes of the stimulus and that the animals’ behavior can be decoded from the activity of those neurons with a high degree of accuracy. Surprisingly, this was also the case in mice in which auditory cortical input to the midbrain had been removed by bilateral cortical lesions. This illustrates that subcortical auditory structures have access to a wealth of non-acoustic information and can, independently of the auditory cortex, carry much richer neural representations than previously thought.https://elifesciences.org/articles/89950auditorymidbraincortexsound detectioncorticocollicularfeedback |
| spellingShingle | Tai-Ying Lee Yves Weissenberger Andrew J King Johannes C Dahmen Midbrain encodes sound detection behavior without auditory cortex eLife auditory midbrain cortex sound detection corticocollicular feedback |
| title | Midbrain encodes sound detection behavior without auditory cortex |
| title_full | Midbrain encodes sound detection behavior without auditory cortex |
| title_fullStr | Midbrain encodes sound detection behavior without auditory cortex |
| title_full_unstemmed | Midbrain encodes sound detection behavior without auditory cortex |
| title_short | Midbrain encodes sound detection behavior without auditory cortex |
| title_sort | midbrain encodes sound detection behavior without auditory cortex |
| topic | auditory midbrain cortex sound detection corticocollicular feedback |
| url | https://elifesciences.org/articles/89950 |
| work_keys_str_mv | AT taiyinglee midbrainencodessounddetectionbehaviorwithoutauditorycortex AT yvesweissenberger midbrainencodessounddetectionbehaviorwithoutauditorycortex AT andrewjking midbrainencodessounddetectionbehaviorwithoutauditorycortex AT johannescdahmen midbrainencodessounddetectionbehaviorwithoutauditorycortex |