Macrophages inhibit Coxiella burnetii by the ACOD1‐itaconate pathway for containment of Q fever

Macrophages inhibit Coxiella burnetii by the ACOD1‐itaconate pathway for containment of Q fever

Abstract Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis‐aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fe...

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Main Authors: Lisa Kohl, Md Nur A Alam Siddique, Barbara Bodendorfer, Raffaela Berger, Annica Preikschat, Christoph Daniel, Martha Ölke, Elisabeth Liebler‐Tenorio, Jan Schulze‐Luehrmann, Michael Mauermeir, Kai‐Ting Yang, Inaya Hayek, Manuela Szperlinski, Jennifer Andrack, Ulrike Schleicher, Aline Bozec, Gerhard Krönke, Peter J Murray, Stefan Wirtz, Masahiro Yamamoto, Valentin Schatz, Jonathan Jantsch, Peter Oefner, Daniel Degrandi, Klaus Pfeffer, Katja Mertens‐Scholz, Simon Rauber, Christian Bogdan, Katja Dettmer, Anja Lührmann, Roland Lang
Format: Article
Language:English
Published: Springer Nature 2022-12-01
Series:EMBO Molecular Medicine
Subjects:
Cis‐aconitate decarboxylase 1
Coxiella burnetii
Immune responsive gene 1
immunometabolism
itaconate
Online Access:https://doi.org/10.15252/emmm.202215931
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