Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double Diagnosis
Gastric duplication cysts (GDCs) are rare congenital anomalies, often identified during infancy or childhood. Although typically benign, there have been sporadic reports of malignant transformations, including adenocarcinoma and rare mixed tumors. Herein, we describe a rare case of mixed pancreatobi...
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MDPI AG
2024-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/23/2727 |
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| author | Minhye Kim Jungwook Yang Daehyun Song Hyojung An Dongchul Kim |
| author_facet | Minhye Kim Jungwook Yang Daehyun Song Hyojung An Dongchul Kim |
| author_sort | Minhye Kim |
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| description | Gastric duplication cysts (GDCs) are rare congenital anomalies, often identified during infancy or childhood. Although typically benign, there have been sporadic reports of malignant transformations, including adenocarcinoma and rare mixed tumors. Herein, we describe a rare case of mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma occurring within a GDC in a 54-year-old Korean woman with a history of melena and hematemesis. Initial gastroscopy and positron emission tomography–computed tomography (PET-CT) revealed a protruding stomach mass. A laparoscopic total gastrectomy was performed, and histological examination confirmed a mixed carcinoma originating from an ectopic pancreas within the duplication cyst. This case is unique as it is the first reported instance in the world of mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma arising from an ectopic pancreas within a GDC. This highlights the importance of considering pancreatobiliary-type adenocarcinoma in the differential diagnosis of malignancies originating from GDCs, which has implications for treatment strategies. |
| format | Article |
| id | doaj-art-1b4ba7a2832145649e3578fc9d0d6c1f |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-1b4ba7a2832145649e3578fc9d0d6c1f2024-12-13T16:24:49ZengMDPI AGDiagnostics2075-44182024-12-011423272710.3390/diagnostics14232727Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double DiagnosisMinhye Kim0Jungwook Yang1Daehyun Song2Hyojung An3Dongchul Kim4Department of Pathology, Gyeongsang National University Hospital, Jinju 52727, Republic of KoreaDepartment of Pathology, Gyeongsang National University Hospital, Jinju 52727, Republic of KoreaDepartment of Pathology, Gyeongsang National University School of Medicine, Jinju 52727, Republic of KoreaDepartment of Pathology, Gyeongsang National University School of Medicine, Jinju 52727, Republic of KoreaDepartment of Pathology, Gyeongsang National University Hospital, Jinju 52727, Republic of KoreaGastric duplication cysts (GDCs) are rare congenital anomalies, often identified during infancy or childhood. Although typically benign, there have been sporadic reports of malignant transformations, including adenocarcinoma and rare mixed tumors. Herein, we describe a rare case of mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma occurring within a GDC in a 54-year-old Korean woman with a history of melena and hematemesis. Initial gastroscopy and positron emission tomography–computed tomography (PET-CT) revealed a protruding stomach mass. A laparoscopic total gastrectomy was performed, and histological examination confirmed a mixed carcinoma originating from an ectopic pancreas within the duplication cyst. This case is unique as it is the first reported instance in the world of mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma arising from an ectopic pancreas within a GDC. This highlights the importance of considering pancreatobiliary-type adenocarcinoma in the differential diagnosis of malignancies originating from GDCs, which has implications for treatment strategies.https://www.mdpi.com/2075-4418/14/23/2727adenocarcinomagastric duplication cystsectopic pancreas |
| spellingShingle | Minhye Kim Jungwook Yang Daehyun Song Hyojung An Dongchul Kim Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double Diagnosis Diagnostics adenocarcinoma gastric duplication cysts ectopic pancreas |
| title | Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double Diagnosis |
| title_full | Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double Diagnosis |
| title_fullStr | Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double Diagnosis |
| title_full_unstemmed | Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double Diagnosis |
| title_short | Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double Diagnosis |
| title_sort | mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma arising from an ectopic pancreas in a gastric duplication cyst a rare double diagnosis |
| topic | adenocarcinoma gastric duplication cysts ectopic pancreas |
| url | https://www.mdpi.com/2075-4418/14/23/2727 |
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