The Role of Interleukin-1Beta and Other Potential Genetic Markers as Indicators of Gastric Cancer Risk
Helicobacter pylori infects half of the world’s population, and is associated with asymptomatic gastritis and also with more serious conditions such as peptic ulcer disease and gastric carcinoma. The clinical outcome is largely dependent on the severity and distribution of the H pylori-induced gastr...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/397060 |
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| Summary: | Helicobacter pylori infects half of the world’s population, and is associated
with asymptomatic gastritis and also with more serious conditions
such as peptic ulcer disease and gastric carcinoma. The clinical
outcome is largely dependent on the severity and distribution of the
H pylori-induced gastritis, but the pathogenesis remains poorly understood.
Bacterial virulence factors and environmental influences contribute
to the pathogenesis, but do not explain the divergent
outcomes. There is emerging evidence that host genetic factors play
a key role in determining the clinical outcome of H pylori infection.
In particular, proinflammatory genotypes of the interleukin-1 beta
(IL-1β) gene are associated with an increased risk of gastric cancer
and its precursors. The effects are most likely mediated through the
induction of hypochlorhydria and severe corpus gastritis with the
subsequent development of gastric atrophy. The roles of IL-1β and
other host genetic factors in the pathogenesis of H pylori related cancer
are discussed in this article. |
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| ISSN: | 0835-7900 |