Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients
Abstract Brain white matter disruptions have been implicated in contributing to fatigue, brain fog and other central symptoms commonly reported in inflammatory diseases. In this study, we included 252 RA patients with 756 age and sex matched controls and 240 UC patients with 720 age and sex matched...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-83559-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559484765306880 |
|---|---|
| author | Jennifer G. Cox James H. Cole Matthew J. Kempton Steven C. R. Williams Marius de Groot |
| author_facet | Jennifer G. Cox James H. Cole Matthew J. Kempton Steven C. R. Williams Marius de Groot |
| author_sort | Jennifer G. Cox |
| collection | DOAJ |
| description | Abstract Brain white matter disruptions have been implicated in contributing to fatigue, brain fog and other central symptoms commonly reported in inflammatory diseases. In this study, we included 252 RA patients with 756 age and sex matched controls and 240 UC patients with 720 age and sex matched controls using the UK Biobank imaging dataset. We looked for differences in total volume of white matter hyperintensities (WMH) between patients compared to controls. Then, using voxelwise analysis, we explored the spatial distribution of these white matter hyperintensities and differences in these between patients and controls and between disease groups. A significantly higher volume of WMH was observed in both the RA (p = 1.9 × 10−8, β = − 0.36, 95% CI = − 0.48, − 0.23) and UC (p = 0.003, β = − 0.18 95% CI = − 0.31, − 0.06) patients compared to their respective control groups. Voxelwise analysis revealed only a small cluster of RA associated WMH compared to controls. These results indicate an increased risk of white matter hyperintensities in patients with RA and UC. These findings help quantify the effect of inflammation from autoimmune diseases on cerebrovascular health and white matter integrity. |
| format | Article |
| id | doaj-art-1b4a14dfcf1d490c94150887d3fbaacd |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-1b4a14dfcf1d490c94150887d3fbaacd2025-01-05T12:27:02ZengNature PortfolioScientific Reports2045-23222024-12-0114111010.1038/s41598-024-83559-1Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patientsJennifer G. Cox0James H. Cole1Matthew J. Kempton2Steven C. R. Williams3Marius de Groot4Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonCentre for Medical Image Computing, Department of Computer Science, University College LondonCentre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonCentre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonCentre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonAbstract Brain white matter disruptions have been implicated in contributing to fatigue, brain fog and other central symptoms commonly reported in inflammatory diseases. In this study, we included 252 RA patients with 756 age and sex matched controls and 240 UC patients with 720 age and sex matched controls using the UK Biobank imaging dataset. We looked for differences in total volume of white matter hyperintensities (WMH) between patients compared to controls. Then, using voxelwise analysis, we explored the spatial distribution of these white matter hyperintensities and differences in these between patients and controls and between disease groups. A significantly higher volume of WMH was observed in both the RA (p = 1.9 × 10−8, β = − 0.36, 95% CI = − 0.48, − 0.23) and UC (p = 0.003, β = − 0.18 95% CI = − 0.31, − 0.06) patients compared to their respective control groups. Voxelwise analysis revealed only a small cluster of RA associated WMH compared to controls. These results indicate an increased risk of white matter hyperintensities in patients with RA and UC. These findings help quantify the effect of inflammation from autoimmune diseases on cerebrovascular health and white matter integrity.https://doi.org/10.1038/s41598-024-83559-1Autoimmune diseasesWhite matter hyperintensitiesUlcerative colitisRheumatoid arthritisSystemic inflammationMagnetic resonance imaging |
| spellingShingle | Jennifer G. Cox James H. Cole Matthew J. Kempton Steven C. R. Williams Marius de Groot Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients Scientific Reports Autoimmune diseases White matter hyperintensities Ulcerative colitis Rheumatoid arthritis Systemic inflammation Magnetic resonance imaging |
| title | Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients |
| title_full | Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients |
| title_fullStr | Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients |
| title_full_unstemmed | Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients |
| title_short | Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients |
| title_sort | volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients |
| topic | Autoimmune diseases White matter hyperintensities Ulcerative colitis Rheumatoid arthritis Systemic inflammation Magnetic resonance imaging |
| url | https://doi.org/10.1038/s41598-024-83559-1 |
| work_keys_str_mv | AT jennifergcox volumeanddistributionofwhitematterhyperintensitiesinrheumatoidarthritisandulcerativecolitispatients AT jameshcole volumeanddistributionofwhitematterhyperintensitiesinrheumatoidarthritisandulcerativecolitispatients AT matthewjkempton volumeanddistributionofwhitematterhyperintensitiesinrheumatoidarthritisandulcerativecolitispatients AT stevencrwilliams volumeanddistributionofwhitematterhyperintensitiesinrheumatoidarthritisandulcerativecolitispatients AT mariusdegroot volumeanddistributionofwhitematterhyperintensitiesinrheumatoidarthritisandulcerativecolitispatients |