Knockdown of Gfi1 increases BMSCs exosomal miR-150-3p to inhibit osteoblast ferroptosis in steroid-induced osteonecrosis of the femoral head through BTRC/Nrf2 axis

Knockdown of Gfi1 increases BMSCs exosomal miR-150-3p to inhibit osteoblast ferroptosis in steroid-induced osteonecrosis of the femoral head through BTRC/Nrf2 axis

The ferroptosis of osteoblasts has been demonstrated to play a significant role in the development of steroid-induced osteonecrosis of the femoral head (SONFH). Additionally, microRNAs (miRNAs) have been identified as regulators of SONFH progression. However, the precise role of miRNAs in the regula...

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Bibliographic Details
Main Authors: Liwen Zheng, Changjie Zhang, Lele Liao, Zhijie Hai, Xin Luo, Haoliang Xiao
Format: Article
Language:English
Published: The Japan Endocrine Society 2025-02-01
Series:Endocrine Journal
Subjects:
steroid-induced osteonecrosis of the femoral head (sonfh)
ferroptosis
growth factor independence 1 (gfi1)
mir-150-3p
beta-transducin repeat containing e3 ubiquitin protein ligase (btrc)
Online Access:https://www.jstage.jst.go.jp/article/endocrj/72/2/72_EJ24-0306/_html/-char/en
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