Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging
Abstract Background To evaluate the utility of glucose chemical exchange saturation transfer (glucoCEST) MRI with non-contrast injection in predicting the histological grade of rectal cancer. Methods This prospective analysis included 60 patients with preoperative rectal cancer who underwent pelvic...
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2024-11-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-024-01828-z |
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| author | Nan Meng Zhun Huang Han Jiang Bo Dai Lei Shen Xue Liu Yaping Wu Xuan Yu Fangfang Fu Zheng Li Zhiwei Shen Baiyan Jiang Meiyun Wang |
| author_facet | Nan Meng Zhun Huang Han Jiang Bo Dai Lei Shen Xue Liu Yaping Wu Xuan Yu Fangfang Fu Zheng Li Zhiwei Shen Baiyan Jiang Meiyun Wang |
| author_sort | Nan Meng |
| collection | DOAJ |
| description | Abstract Background To evaluate the utility of glucose chemical exchange saturation transfer (glucoCEST) MRI with non-contrast injection in predicting the histological grade of rectal cancer. Methods This prospective analysis included 60 patients with preoperative rectal cancer who underwent pelvic glucoCEST, amide proton transfer-weighted imaging (APTWI), and diffusion-weighted imaging (DWI). In total, 21 low-grade and 39 high-grade cases were confirmed by postoperative pathology. The MTRasym (1.2 ppm), MTRasym (3.5 ppm), and apparent diffusion coefficient (ADC) values of lesions between the low-grade and high-grade groups were compared. The area under the receiver operating characteristic curve (AUC) was generated to evaluate the diagnostic performance of each technique. Logistic regression (LR) analysis was applied to determine independent predictors and for multi-parameter combined diagnosis. Results Elevated MTRasym (1.2 ppm), MTRasym (3.5 ppm) values and lower ADC values were observed in the high-grade group compared with low-grade cases (all p < 0.01). The AUCs of MTRasym (1.2 ppm), MTRasym (3.5 ppm), and ADC for differentiating between low- and high-grade rectal cancer cases were 0.792, 0.839, and 0.855, respectively. The diagnostic performance of the combination of the three indexes was improved (AUC, 0.969; sensitivity, 95.24%; specificity, 87.18%). The good consistency and reliability of the combination of independent predictors were demonstrated by calibration curve analysis and DCA. Conclusion The glucoCEST MRI without contrast injection, APTWI, and DWI all facilitate the assessment of histological grade in rectal cancer, and the combination of the three can effectively discriminate between high- and low-grade rectal cancer, which is expected to be a promising imaging marker. Critical relevance statement The glucose chemical exchange saturation transfer MRI method facilitates the assessment of histological grade in rectal cancer and offers additional information to improve the diagnostic performance of amide proton transfer-weighted imaging, and diffusion-weighted imaging. Key Points Glucose chemical exchange saturation transfer imaging could differentiate histological grade. Amide proton transfer-weighted and diffusion-weighted were associated with histological grade. The combination of different parameters showed the best diagnostic performance. Graphical Abstract |
| format | Article |
| id | doaj-art-1b3affe9b3874f27bd129e13e9eda8fe |
| institution | Kabale University |
| issn | 1869-4101 |
| language | English |
| publishDate | 2024-11-01 |
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| spelling | doaj-art-1b3affe9b3874f27bd129e13e9eda8fe2024-11-17T12:31:52ZengSpringerOpenInsights into Imaging1869-41012024-11-0115111110.1186/s13244-024-01828-zGlucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imagingNan Meng0Zhun Huang1Han Jiang2Bo Dai3Lei Shen4Xue Liu5Yaping Wu6Xuan Yu7Fangfang Fu8Zheng Li9Zhiwei Shen10Baiyan Jiang11Meiyun Wang12Department of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalDepartment of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalDepartment of Radiology, Xinxiang Medical University Henan Provincial People’s HospitalDepartment of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalDepartment of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalDepartment of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalDepartment of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalDepartment of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalDepartment of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalDepartment of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalPhilips HealthcarePhilips HealthcareDepartment of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s HospitalAbstract Background To evaluate the utility of glucose chemical exchange saturation transfer (glucoCEST) MRI with non-contrast injection in predicting the histological grade of rectal cancer. Methods This prospective analysis included 60 patients with preoperative rectal cancer who underwent pelvic glucoCEST, amide proton transfer-weighted imaging (APTWI), and diffusion-weighted imaging (DWI). In total, 21 low-grade and 39 high-grade cases were confirmed by postoperative pathology. The MTRasym (1.2 ppm), MTRasym (3.5 ppm), and apparent diffusion coefficient (ADC) values of lesions between the low-grade and high-grade groups were compared. The area under the receiver operating characteristic curve (AUC) was generated to evaluate the diagnostic performance of each technique. Logistic regression (LR) analysis was applied to determine independent predictors and for multi-parameter combined diagnosis. Results Elevated MTRasym (1.2 ppm), MTRasym (3.5 ppm) values and lower ADC values were observed in the high-grade group compared with low-grade cases (all p < 0.01). The AUCs of MTRasym (1.2 ppm), MTRasym (3.5 ppm), and ADC for differentiating between low- and high-grade rectal cancer cases were 0.792, 0.839, and 0.855, respectively. The diagnostic performance of the combination of the three indexes was improved (AUC, 0.969; sensitivity, 95.24%; specificity, 87.18%). The good consistency and reliability of the combination of independent predictors were demonstrated by calibration curve analysis and DCA. Conclusion The glucoCEST MRI without contrast injection, APTWI, and DWI all facilitate the assessment of histological grade in rectal cancer, and the combination of the three can effectively discriminate between high- and low-grade rectal cancer, which is expected to be a promising imaging marker. Critical relevance statement The glucose chemical exchange saturation transfer MRI method facilitates the assessment of histological grade in rectal cancer and offers additional information to improve the diagnostic performance of amide proton transfer-weighted imaging, and diffusion-weighted imaging. Key Points Glucose chemical exchange saturation transfer imaging could differentiate histological grade. Amide proton transfer-weighted and diffusion-weighted were associated with histological grade. The combination of different parameters showed the best diagnostic performance. Graphical Abstracthttps://doi.org/10.1186/s13244-024-01828-zRectal neoplasmsNeoplasm gradingGlucoseMagnetization transfer contrast imagingDiffusion magnetic resonance imaging |
| spellingShingle | Nan Meng Zhun Huang Han Jiang Bo Dai Lei Shen Xue Liu Yaping Wu Xuan Yu Fangfang Fu Zheng Li Zhiwei Shen Baiyan Jiang Meiyun Wang Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging Insights into Imaging Rectal neoplasms Neoplasm grading Glucose Magnetization transfer contrast imaging Diffusion magnetic resonance imaging |
| title | Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging |
| title_full | Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging |
| title_fullStr | Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging |
| title_full_unstemmed | Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging |
| title_short | Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging |
| title_sort | glucose chemical exchange saturation transfer mri for predicting the histological grade of rectal cancer a comparative study with amide proton transfer weighted and diffusion weighted imaging |
| topic | Rectal neoplasms Neoplasm grading Glucose Magnetization transfer contrast imaging Diffusion magnetic resonance imaging |
| url | https://doi.org/10.1186/s13244-024-01828-z |
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