Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks
Background Bronchiectasis is a disease with predominantly neutrophilic inflammation. As a readily available biomarker, there is little evidence to support the use of blood neutrophil-to-lymphocyte ratio (NLR) to predict bronchiectasis exacerbation severe enough to warrant hospitalization.Methods A r...
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Taylor & Francis Group
2024-12-01
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| Series: | European Clinical Respiratory Journal |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20018525.2024.2372901 |
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| author | Wang Chun Kwok James Chung Man Ho David Chi Leung Lam Mary Sau Man Ip Terence Chi Chun Tam |
| author_facet | Wang Chun Kwok James Chung Man Ho David Chi Leung Lam Mary Sau Man Ip Terence Chi Chun Tam |
| author_sort | Wang Chun Kwok |
| collection | DOAJ |
| description | Background Bronchiectasis is a disease with predominantly neutrophilic inflammation. As a readily available biomarker, there is little evidence to support the use of blood neutrophil-to-lymphocyte ratio (NLR) to predict bronchiectasis exacerbation severe enough to warrant hospitalization.Methods A registry-based retrospective cohort study was conducted at a in Hong Kong. Chinese patients with non-cystic fibrosis (CF) bronchiectasis were retrospectively reviewed and subsequently followed up to investigate the association of NLR and the need for hospitalization for bronchiectasis exacerbation. Data on the NLR for patients in a clinically stable state in 2018 were collected and patients followed up from 1 January 2019 to 31 December 2022. The primary outcome was the need for hospitalization due to bronchiectasis exacerbation over the next 4 years.Results We reviewed 473 Chinese patients with non-CF bronchiectasis, of whom 94 required hospitalization for bronchiectasis exacerbation during the 4-year follow-up period. Multi-variable logistic regression adjusted for E-FACED score (Exacerbation, Forced expiratory volume in 1 s (FEV1), Age, Chronic colonization, Extension, and Dyspnea score), gender, age, smoking status, and presence of co-existing chronic obstructive pulmonary disease (COPD) was conducted to compare patients with highest and lowest quartile NLR. Results revealed that those with NLR at the highest quartile were at increased risk of hospitalization for bronchiectasis exacerbation with an adjusted odds ratio (aOR) of 2.02 (95% confidence interval = 1.00–4.12, p = 0.05).Conclusion Blood NLR may serve as a marker to predict the need for hospitalization due to bronchiectasis exacerbation. |
| format | Article |
| id | doaj-art-1b271baee84b4a609fa0d56f5e200b1a |
| institution | Kabale University |
| issn | 2001-8525 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Clinical Respiratory Journal |
| spelling | doaj-art-1b271baee84b4a609fa0d56f5e200b1a2024-11-27T18:28:18ZengTaylor & Francis GroupEuropean Clinical Respiratory Journal2001-85252024-12-0111110.1080/20018525.2024.2372901Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risksWang Chun Kwok0James Chung Man Ho1David Chi Leung Lam2Mary Sau Man Ip3Terence Chi Chun Tam4Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, ChinaDepartment of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, ChinaDepartment of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, ChinaDepartment of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, ChinaDepartment of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, ChinaBackground Bronchiectasis is a disease with predominantly neutrophilic inflammation. As a readily available biomarker, there is little evidence to support the use of blood neutrophil-to-lymphocyte ratio (NLR) to predict bronchiectasis exacerbation severe enough to warrant hospitalization.Methods A registry-based retrospective cohort study was conducted at a in Hong Kong. Chinese patients with non-cystic fibrosis (CF) bronchiectasis were retrospectively reviewed and subsequently followed up to investigate the association of NLR and the need for hospitalization for bronchiectasis exacerbation. Data on the NLR for patients in a clinically stable state in 2018 were collected and patients followed up from 1 January 2019 to 31 December 2022. The primary outcome was the need for hospitalization due to bronchiectasis exacerbation over the next 4 years.Results We reviewed 473 Chinese patients with non-CF bronchiectasis, of whom 94 required hospitalization for bronchiectasis exacerbation during the 4-year follow-up period. Multi-variable logistic regression adjusted for E-FACED score (Exacerbation, Forced expiratory volume in 1 s (FEV1), Age, Chronic colonization, Extension, and Dyspnea score), gender, age, smoking status, and presence of co-existing chronic obstructive pulmonary disease (COPD) was conducted to compare patients with highest and lowest quartile NLR. Results revealed that those with NLR at the highest quartile were at increased risk of hospitalization for bronchiectasis exacerbation with an adjusted odds ratio (aOR) of 2.02 (95% confidence interval = 1.00–4.12, p = 0.05).Conclusion Blood NLR may serve as a marker to predict the need for hospitalization due to bronchiectasis exacerbation.https://www.tandfonline.com/doi/10.1080/20018525.2024.2372901Bronchiectasisbronchiectasis exacerbationphenotypeneutrophil to lymphocyte ratiobiomarkers |
| spellingShingle | Wang Chun Kwok James Chung Man Ho David Chi Leung Lam Mary Sau Man Ip Terence Chi Chun Tam Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks European Clinical Respiratory Journal Bronchiectasis bronchiectasis exacerbation phenotype neutrophil to lymphocyte ratio biomarkers |
| title | Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks |
| title_full | Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks |
| title_fullStr | Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks |
| title_full_unstemmed | Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks |
| title_short | Baseline neutrophil-to-lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks |
| title_sort | baseline neutrophil to lymphocyte ratio as a predictor of response to hospitalized bronchiectasis exacerbation risks |
| topic | Bronchiectasis bronchiectasis exacerbation phenotype neutrophil to lymphocyte ratio biomarkers |
| url | https://www.tandfonline.com/doi/10.1080/20018525.2024.2372901 |
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