Emerging roles of N6-methyladenosine in arsenic-induced toxicity
Arsenic can cause extensive toxic damage after entering the body of humans and animals by altering a variety of events. As the most common form of methylation modification of RNA in eukaryotic cells, N6-methyladenosine (m6A) is widely involved in regulating RNA processing, translation and degradatio...
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| Language: | English |
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Elsevier
2024-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024165048 |
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| author | Rongxian Li Chaojie Wu Yuan Zhao Shiyi Jiang Junben Huang Xiuyun Huo Chang Deng Zuoshun He Shiyan Gu Jie Yang |
| author_facet | Rongxian Li Chaojie Wu Yuan Zhao Shiyi Jiang Junben Huang Xiuyun Huo Chang Deng Zuoshun He Shiyan Gu Jie Yang |
| author_sort | Rongxian Li |
| collection | DOAJ |
| description | Arsenic can cause extensive toxic damage after entering the body of humans and animals by altering a variety of events. As the most common form of methylation modification of RNA in eukaryotic cells, N6-methyladenosine (m6A) is widely involved in regulating RNA processing, translation and degradation, thus playing important role in various pathophysiological processes. Emerging studies have demonstrated that m6A modification is synergistically mediated by methyltransferases, demethylases and methyl-binding proteins. Recently, emerging studies have shown that m6A modification and its regulatory proteins play important roles in arsenic toxicity through mediating various key signaling pathways. We comprehensively analyzed the mechanisms by which m6A modification and its regulatory proteins contribute to arsenic toxicity. Our reviews offer a scientific foundation for the development of preventive and control strategies to mitigate arsenic-induced toxicity, with an emphasis on an epigenetic approach. |
| format | Article |
| id | doaj-art-1b2342dd1abb44b48fcadc5bc49061a0 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-1b2342dd1abb44b48fcadc5bc49061a02024-11-30T07:13:06ZengElsevierHeliyon2405-84402024-11-011022e40473Emerging roles of N6-methyladenosine in arsenic-induced toxicityRongxian Li0Chaojie Wu1Yuan Zhao2Shiyi Jiang3Junben Huang4Xiuyun Huo5Chang Deng6Zuoshun He7Shiyan Gu8Jie Yang9School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, ChinaSchool of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, ChinaSchool of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, ChinaSchool of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, ChinaSchool of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, ChinaSchool of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, ChinaSchool of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, ChinaSchool of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, ChinaSchool of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China; Corresponding author. Institute of Preventive Medicine, School of Public Health, Dali University, No. 22, Wanhua Road, Dali, 671000, Yunnan, China.College of Engineering, Dali University, Dali, Yunnan, China; Corresponding author. College of Engineering, Dali University, Dali 671000, Yunnan, China.Arsenic can cause extensive toxic damage after entering the body of humans and animals by altering a variety of events. As the most common form of methylation modification of RNA in eukaryotic cells, N6-methyladenosine (m6A) is widely involved in regulating RNA processing, translation and degradation, thus playing important role in various pathophysiological processes. Emerging studies have demonstrated that m6A modification is synergistically mediated by methyltransferases, demethylases and methyl-binding proteins. Recently, emerging studies have shown that m6A modification and its regulatory proteins play important roles in arsenic toxicity through mediating various key signaling pathways. We comprehensively analyzed the mechanisms by which m6A modification and its regulatory proteins contribute to arsenic toxicity. Our reviews offer a scientific foundation for the development of preventive and control strategies to mitigate arsenic-induced toxicity, with an emphasis on an epigenetic approach.http://www.sciencedirect.com/science/article/pii/S2405844024165048Arsenic toxicityN6-methyladenosineMethyltransferaseDemethylaseMethyl-binding proteins |
| spellingShingle | Rongxian Li Chaojie Wu Yuan Zhao Shiyi Jiang Junben Huang Xiuyun Huo Chang Deng Zuoshun He Shiyan Gu Jie Yang Emerging roles of N6-methyladenosine in arsenic-induced toxicity Heliyon Arsenic toxicity N6-methyladenosine Methyltransferase Demethylase Methyl-binding proteins |
| title | Emerging roles of N6-methyladenosine in arsenic-induced toxicity |
| title_full | Emerging roles of N6-methyladenosine in arsenic-induced toxicity |
| title_fullStr | Emerging roles of N6-methyladenosine in arsenic-induced toxicity |
| title_full_unstemmed | Emerging roles of N6-methyladenosine in arsenic-induced toxicity |
| title_short | Emerging roles of N6-methyladenosine in arsenic-induced toxicity |
| title_sort | emerging roles of n6 methyladenosine in arsenic induced toxicity |
| topic | Arsenic toxicity N6-methyladenosine Methyltransferase Demethylase Methyl-binding proteins |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024165048 |
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