Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy
Abstract Diabetic peripheral neuropathy is a common complication of diabetes mellitus that has dire outcomes, affecting the economic profile of a country. Despite the multifactorial background of the pathogenesis of this disease, the mechanism underlying peripheral neuropathy is still unclear. Endot...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-68790-0 |
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| author | Prajna Parimita Jena Rachita Nanda Amritava Ghosh Suprava Patel Seema Shah Eli Mohapatra |
| author_facet | Prajna Parimita Jena Rachita Nanda Amritava Ghosh Suprava Patel Seema Shah Eli Mohapatra |
| author_sort | Prajna Parimita Jena |
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| description | Abstract Diabetic peripheral neuropathy is a common complication of diabetes mellitus that has dire outcomes, affecting the economic profile of a country. Despite the multifactorial background of the pathogenesis of this disease, the mechanism underlying peripheral neuropathy is still unclear. Endothelial damage is a new determinant of pathogenesis, with endocan as a potential biomarker for endothelial dysfunction in diabetic peripheral neuropathy patients. In this cross-sectional study, with 49 patients with diabetes with peripheral neuropathy and 48 patients with diabetes without neuropathy, endothelial biomarkers such as endocan, hs-CRP, vitamin D, and lipid profiles were measured and analyzed in both groups. The standardized scores for dyslipidemia, inflammation, vitamin D and endocan were calculated. All of these biomarkers were significantly altered in peripheral neuropathy patients. A strong correlation between endocan levels and lipid profiles and between hs-CRP and vitamin D levels was detected. The inflammatory score and a combined score including all the above biomarkers might help in the early stratification of diabetic patients who are at greater risk of developing peripheral neuropathy. |
| format | Article |
| id | doaj-art-1b233c8d45bf47119d7654894a968475 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-1b233c8d45bf47119d7654894a9684752025-01-05T12:20:33ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-024-68790-0Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathyPrajna Parimita Jena0Rachita Nanda1Amritava Ghosh2Suprava Patel3Seema Shah4Eli Mohapatra5Department of Biochemistry, All India Institute of Medical Sciences Raipur, GE Road, Tatibandh. RaipurDepartment of Biochemistry, All India Institute of Medical Sciences Raipur, GE Road, Tatibandh. RaipurDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences RaipurDepartment of Biochemistry, All India Institute of Medical Sciences Raipur, GE Road, Tatibandh. RaipurDepartment of Biochemistry, All India Institute of Medical Sciences Raipur, GE Road, Tatibandh. RaipurDepartment of Biochemistry, All India Institute of Medical Sciences Raipur, GE Road, Tatibandh. RaipurAbstract Diabetic peripheral neuropathy is a common complication of diabetes mellitus that has dire outcomes, affecting the economic profile of a country. Despite the multifactorial background of the pathogenesis of this disease, the mechanism underlying peripheral neuropathy is still unclear. Endothelial damage is a new determinant of pathogenesis, with endocan as a potential biomarker for endothelial dysfunction in diabetic peripheral neuropathy patients. In this cross-sectional study, with 49 patients with diabetes with peripheral neuropathy and 48 patients with diabetes without neuropathy, endothelial biomarkers such as endocan, hs-CRP, vitamin D, and lipid profiles were measured and analyzed in both groups. The standardized scores for dyslipidemia, inflammation, vitamin D and endocan were calculated. All of these biomarkers were significantly altered in peripheral neuropathy patients. A strong correlation between endocan levels and lipid profiles and between hs-CRP and vitamin D levels was detected. The inflammatory score and a combined score including all the above biomarkers might help in the early stratification of diabetic patients who are at greater risk of developing peripheral neuropathy.https://doi.org/10.1038/s41598-024-68790-0Blood-nerve barrierCytokinesDIVE scoreDyslipidemiaEndothelialInflammation |
| spellingShingle | Prajna Parimita Jena Rachita Nanda Amritava Ghosh Suprava Patel Seema Shah Eli Mohapatra Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy Scientific Reports Blood-nerve barrier Cytokines DIVE score Dyslipidemia Endothelial Inflammation |
| title | Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy |
| title_full | Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy |
| title_fullStr | Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy |
| title_full_unstemmed | Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy |
| title_short | Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy |
| title_sort | endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy |
| topic | Blood-nerve barrier Cytokines DIVE score Dyslipidemia Endothelial Inflammation |
| url | https://doi.org/10.1038/s41598-024-68790-0 |
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