Lympho-vascular invasion in oral cavity cancers – A bridge between tumour biology and clinical outcomes
Objective: Various histo-pathological prognostic factors have been identified in oral cavity squamous cell carcinomas (OCSCC). One such factor is the status of lympho-vascular invasion (LVI). We carried out this analysis to evaluate the association of LVI with other prognostic factors and the clinic...
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Elsevier
2024-09-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024003236 |
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| author | Sapna Krishnamurthy Imtiaz Ahmed Kumar Vinchurkar Mahesh Kalloli Adarsh Sanikop Raghavendra Sagar Santosh Mathapathi Rohan Bhise |
| author_facet | Sapna Krishnamurthy Imtiaz Ahmed Kumar Vinchurkar Mahesh Kalloli Adarsh Sanikop Raghavendra Sagar Santosh Mathapathi Rohan Bhise |
| author_sort | Sapna Krishnamurthy |
| collection | DOAJ |
| description | Objective: Various histo-pathological prognostic factors have been identified in oral cavity squamous cell carcinomas (OCSCC). One such factor is the status of lympho-vascular invasion (LVI). We carried out this analysis to evaluate the association of LVI with other prognostic factors and the clinical outcomes. Methods: Data of patients with OCSCC who underwent curative intent surgery from January-2017 to December-2019 at our institute were retrospectively evaluated. The association of LVI with various tumour-node related prognostic factors and its effect on overall and disease-free survival (OS, DFS) were analyzed. Results: of the total 234 patients, 71 % (166) had Bucco-alveolar-complex primary. 62.8 % (147) had locoregionally advanced disease. 91.5 % (214) required adjuvant treatment.The LVI positivity was 77.4 %, 63.3 % in tumour size >3cm/<3 cm, 85 %, 59.7 % in depth of infiltration >1cm/<1 cm, 82.4 %, 57.6 % in T3-T4/T1-2, 91.9 %, 59.9 % in grade 3/others and 96.8 %, 13.8 % in perineural invasion present/absent, respectively (p < 0.05). In the presence of LVI, lymph node positivity was 60.6 %, N2–N3 were 41.9 % and extra-capsular extension was 26.9 % as compared to LVI negative – 5.4 %, 5.4 % and 4.1 % respectively (p < 0.05).With median follow up of 37.3 months, 2year OS and DFS were 76.6 % and 75.5 % respectively. The 2year OS and DFS for the LVI-positive group were 70.4 % and 69.3 % compared to 90.6 % and 89.3 % for LVI-negative (p = 0.00). Loco-regional and distal (any) recurrence was seen in 20.9 % (49) and 7.3 % (17), the same for LVI-positive was 25.6 % (41) and 10 % (16) compared to 10.8 % (8) and 1.4 % (1) for LVI-negative (p < 0.05). Conclusion: In oral cavity cancers, there is positive association of LVI with various tumour-node related prognostic factors and clinical outcomes. |
| format | Article |
| id | doaj-art-1b162cdc1a9e448195da9e26a22f3e3f |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-1b162cdc1a9e448195da9e26a22f3e3f2025-01-09T06:16:27ZengElsevierOral Oncology Reports2772-90602024-09-0111100477Lympho-vascular invasion in oral cavity cancers – A bridge between tumour biology and clinical outcomesSapna Krishnamurthy0Imtiaz Ahmed1Kumar Vinchurkar2Mahesh Kalloli3Adarsh Sanikop4Raghavendra Sagar5Santosh Mathapathi6Rohan Bhise7Department of Radiation Oncology, Jawaharlal Nehru Medical College, KAHER, Nehru Nagar, Belagavi, 590010, Karnataka, India; Corresponding author. Jawaharlal Nehru Medical College, KAHER, Nehru Nagar, Belagavi, 590010, Karnataka, India.Department of Radiation Oncology, Jawaharlal Nehru Medical College, KAHER, Nehru Nagar, Belagavi, 590010, Karnataka, IndiaDepartment of Surgical Oncology, Jawaharlal Nehru Medical College, KAHER, Nehru Nagar, Belagavi, 590010, Karnataka, IndiaDepartment of Surgical Oncology, Jawaharlal Nehru Medical College, KAHER, Nehru Nagar, Belagavi, 590010, Karnataka, IndiaDepartment of Pathology, Jawaharlal Nehru Medical College, KAHER, Nehru Nagar, Belagavi, 590010, Karnataka, IndiaDepartment of Radiation Oncology, Jawaharlal Nehru Medical College, KAHER, Nehru Nagar, Belagavi, 590010, Karnataka, IndiaDepartment of Surgical Oncology, Jawaharlal Nehru Medical College, KAHER, Nehru Nagar, Belagavi, 590010, Karnataka, IndiaDepartment of Medical Oncology, Jawaharlal Nehru Medical College, KAHER, Nehru Nagar, Belagavi, 590010, Karnataka, IndiaObjective: Various histo-pathological prognostic factors have been identified in oral cavity squamous cell carcinomas (OCSCC). One such factor is the status of lympho-vascular invasion (LVI). We carried out this analysis to evaluate the association of LVI with other prognostic factors and the clinical outcomes. Methods: Data of patients with OCSCC who underwent curative intent surgery from January-2017 to December-2019 at our institute were retrospectively evaluated. The association of LVI with various tumour-node related prognostic factors and its effect on overall and disease-free survival (OS, DFS) were analyzed. Results: of the total 234 patients, 71 % (166) had Bucco-alveolar-complex primary. 62.8 % (147) had locoregionally advanced disease. 91.5 % (214) required adjuvant treatment.The LVI positivity was 77.4 %, 63.3 % in tumour size >3cm/<3 cm, 85 %, 59.7 % in depth of infiltration >1cm/<1 cm, 82.4 %, 57.6 % in T3-T4/T1-2, 91.9 %, 59.9 % in grade 3/others and 96.8 %, 13.8 % in perineural invasion present/absent, respectively (p < 0.05). In the presence of LVI, lymph node positivity was 60.6 %, N2–N3 were 41.9 % and extra-capsular extension was 26.9 % as compared to LVI negative – 5.4 %, 5.4 % and 4.1 % respectively (p < 0.05).With median follow up of 37.3 months, 2year OS and DFS were 76.6 % and 75.5 % respectively. The 2year OS and DFS for the LVI-positive group were 70.4 % and 69.3 % compared to 90.6 % and 89.3 % for LVI-negative (p = 0.00). Loco-regional and distal (any) recurrence was seen in 20.9 % (49) and 7.3 % (17), the same for LVI-positive was 25.6 % (41) and 10 % (16) compared to 10.8 % (8) and 1.4 % (1) for LVI-negative (p < 0.05). Conclusion: In oral cavity cancers, there is positive association of LVI with various tumour-node related prognostic factors and clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2772906024003236Lympho-vascular invasionOral cavityTumour biologyOutcomes |
| spellingShingle | Sapna Krishnamurthy Imtiaz Ahmed Kumar Vinchurkar Mahesh Kalloli Adarsh Sanikop Raghavendra Sagar Santosh Mathapathi Rohan Bhise Lympho-vascular invasion in oral cavity cancers – A bridge between tumour biology and clinical outcomes Oral Oncology Reports Lympho-vascular invasion Oral cavity Tumour biology Outcomes |
| title | Lympho-vascular invasion in oral cavity cancers – A bridge between tumour biology and clinical outcomes |
| title_full | Lympho-vascular invasion in oral cavity cancers – A bridge between tumour biology and clinical outcomes |
| title_fullStr | Lympho-vascular invasion in oral cavity cancers – A bridge between tumour biology and clinical outcomes |
| title_full_unstemmed | Lympho-vascular invasion in oral cavity cancers – A bridge between tumour biology and clinical outcomes |
| title_short | Lympho-vascular invasion in oral cavity cancers – A bridge between tumour biology and clinical outcomes |
| title_sort | lympho vascular invasion in oral cavity cancers a bridge between tumour biology and clinical outcomes |
| topic | Lympho-vascular invasion Oral cavity Tumour biology Outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024003236 |
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