Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function
Background: Uranium is a potentially cardiotoxic, nonessential element commonly found in drinking water throughout the United States. Objectives: The purpose of this study was to evaluate if urinary uranium concentrations were associated with measures of cardiac geometry and function among American...
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Elsevier
2024-12-01
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| Series: | JACC: Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772963X24006884 |
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| author | Wil Lieberman-Cribbin, PhD Irene Martinez-Morata, MD, PhD Arce Domingo-Relloso, PhD Jason G. Umans, MD, PhD Shelley A. Cole, PhD Marcia O’Leary, RN Maria Grau-Perez, PhD Gernot Pichler, MD, PhD, MSc Richard B. Devereux, MD Anne E. Nigra, ScM, PhD Allison Kupsco, PhD Ana Navas-Acien, PhD |
| author_facet | Wil Lieberman-Cribbin, PhD Irene Martinez-Morata, MD, PhD Arce Domingo-Relloso, PhD Jason G. Umans, MD, PhD Shelley A. Cole, PhD Marcia O’Leary, RN Maria Grau-Perez, PhD Gernot Pichler, MD, PhD, MSc Richard B. Devereux, MD Anne E. Nigra, ScM, PhD Allison Kupsco, PhD Ana Navas-Acien, PhD |
| author_sort | Wil Lieberman-Cribbin, PhD |
| collection | DOAJ |
| description | Background: Uranium is a potentially cardiotoxic, nonessential element commonly found in drinking water throughout the United States. Objectives: The purpose of this study was to evaluate if urinary uranium concentrations were associated with measures of cardiac geometry and function among American Indian young adults from the Strong Heart Family Study. Methods: Urinary uranium was measured among 1,332 participants free of diabetes, cardiovascular disease, and <50 years of age at baseline (2001-2003). Transthoracic echocardiography and blood pressure were assessed at baseline and at a follow-up visit (2006-2009). We estimated adjusted mean differences in cardiac geometry and function measures at baseline and follow-up using linear mixed-effect models with a random intercept and slope over time. Results: Median (interquartile range) uranium was 0.029 (0.045) μg/g creatinine. In fully adjusted cross-sectional models, a log-doubling of urinary uranium was positively associated with left ventricular (LV) mass index (mean difference: 0.49 g/m2, 95% CI: 0.07-0.92 g/m2), left atrial systolic diameter (0.01 cm/m2, 0.01-0.02 cm/m2), and stroke volume (0.66 mL, 0.25-1.08 mL) at baseline. Prospectively, uranium was associated with increases in left atrial diameter (0.01 cm/m2, 0.01-0.02 cm/m2), pulse pressure (0.28 mm Hg, 0.05-0.52 mm Hg), and incident LV hypertrophy (odds ratio: 1.25, 95% confidence interval: 1.06, 1.48). Conclusions: Urinary uranium levels were adversely associated with measures of cardiac geometry and LV function among American Indian adults, including increases in pulse pressure and LV hypertrophy. These findings support the need to determine the potential long-term subclinical and clinical cardiovascular effects of chronic uranium exposure, and the need for future strategies to reduce exposure. |
| format | Article |
| id | doaj-art-1af6bec815804e1a858a206b73ca7936 |
| institution | Kabale University |
| issn | 2772-963X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | JACC: Advances |
| spelling | doaj-art-1af6bec815804e1a858a206b73ca79362024-11-21T06:07:08ZengElsevierJACC: Advances2772-963X2024-12-01312101408Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular FunctionWil Lieberman-Cribbin, PhD0Irene Martinez-Morata, MD, PhD1Arce Domingo-Relloso, PhD2Jason G. Umans, MD, PhD3Shelley A. Cole, PhD4Marcia O’Leary, RN5Maria Grau-Perez, PhD6Gernot Pichler, MD, PhD, MSc7Richard B. Devereux, MD8Anne E. Nigra, ScM, PhD9Allison Kupsco, PhD10Ana Navas-Acien, PhD11Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA; Address for correspondence: Dr Wil Lieberman-Cribbin, Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722 West 168th Street, New York, New York 10032, USA.Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USADepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, New York, USAGeorgetown-Howard Universities Center for Clinical and Translational Science, Washington DC, USA; MedStar Health Research Institute, Hyattsville, Maryland, USAPopulation Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USAMissouri Breaks Industries Research, Cheyenne River Sioux Tribe, Eagle Butte, South Dakota, USADepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA; Big data and Artificial Intelligence Unit, Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Statistics and Operational Research, University of Valencia, Valencia, SpainDepartment of Cardiology and Karl Landsteiner Institute for Cardiovascular and Critical Care Research, Clinic Floridsdorf, Vienna, AustriaDivision of Cardiology, Weill Cornell Medical College, New York, New York, USADepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USADepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USADepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USABackground: Uranium is a potentially cardiotoxic, nonessential element commonly found in drinking water throughout the United States. Objectives: The purpose of this study was to evaluate if urinary uranium concentrations were associated with measures of cardiac geometry and function among American Indian young adults from the Strong Heart Family Study. Methods: Urinary uranium was measured among 1,332 participants free of diabetes, cardiovascular disease, and <50 years of age at baseline (2001-2003). Transthoracic echocardiography and blood pressure were assessed at baseline and at a follow-up visit (2006-2009). We estimated adjusted mean differences in cardiac geometry and function measures at baseline and follow-up using linear mixed-effect models with a random intercept and slope over time. Results: Median (interquartile range) uranium was 0.029 (0.045) μg/g creatinine. In fully adjusted cross-sectional models, a log-doubling of urinary uranium was positively associated with left ventricular (LV) mass index (mean difference: 0.49 g/m2, 95% CI: 0.07-0.92 g/m2), left atrial systolic diameter (0.01 cm/m2, 0.01-0.02 cm/m2), and stroke volume (0.66 mL, 0.25-1.08 mL) at baseline. Prospectively, uranium was associated with increases in left atrial diameter (0.01 cm/m2, 0.01-0.02 cm/m2), pulse pressure (0.28 mm Hg, 0.05-0.52 mm Hg), and incident LV hypertrophy (odds ratio: 1.25, 95% confidence interval: 1.06, 1.48). Conclusions: Urinary uranium levels were adversely associated with measures of cardiac geometry and LV function among American Indian adults, including increases in pulse pressure and LV hypertrophy. These findings support the need to determine the potential long-term subclinical and clinical cardiovascular effects of chronic uranium exposure, and the need for future strategies to reduce exposure.http://www.sciencedirect.com/science/article/pii/S2772963X24006884American Indian populationscardiac geometryleft ventricular functionuranium |
| spellingShingle | Wil Lieberman-Cribbin, PhD Irene Martinez-Morata, MD, PhD Arce Domingo-Relloso, PhD Jason G. Umans, MD, PhD Shelley A. Cole, PhD Marcia O’Leary, RN Maria Grau-Perez, PhD Gernot Pichler, MD, PhD, MSc Richard B. Devereux, MD Anne E. Nigra, ScM, PhD Allison Kupsco, PhD Ana Navas-Acien, PhD Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function JACC: Advances American Indian populations cardiac geometry left ventricular function uranium |
| title | Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function |
| title_full | Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function |
| title_fullStr | Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function |
| title_full_unstemmed | Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function |
| title_short | Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function |
| title_sort | relationship between urinary uranium and cardiac geometry and left ventricular function |
| topic | American Indian populations cardiac geometry left ventricular function uranium |
| url | http://www.sciencedirect.com/science/article/pii/S2772963X24006884 |
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