Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium Tuberculosis
This review examines the complex interactions between Mycobacterium tuberculosis and host immunity, with a focus on Mtb and immune evasion. Upon inhalation, Mtb infects alveolar macrophages, inhibiting phagosome-lysosome fusion to survive. Dendritic cells are later activated, driving CD4+ T cell dif...
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| Format: | Article |
| Language: | English |
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York University
2025-05-01
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| Series: | Canadian Journal for the Academic Mind |
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| Online Access: | https://cjam.journals.yorku.ca/index.php/default/article/view/99 |
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| author | Eden Sedarous Dima Traboulsi Heeral Dodhia Katey Kwan Suky Zheng Venice Co |
| author_facet | Eden Sedarous Dima Traboulsi Heeral Dodhia Katey Kwan Suky Zheng Venice Co |
| author_sort | Eden Sedarous |
| collection | DOAJ |
| description | This review examines the complex interactions between Mycobacterium tuberculosis and host immunity, with a focus on Mtb and immune evasion. Upon inhalation, Mtb infects alveolar macrophages, inhibiting phagosome-lysosome fusion to survive. Dendritic cells are later activated, driving CD4+ T cell differentiation and IFN-γ release to enhance macrophage bactericidal activity. Mtb may be sequestered in granulomas, which contain the infection but facilitates Mtbpersistence during latency. Further, cytotoxic T lymphocytes eliminate infected cells, while regulatory T cells modulate immunity. Overall, host immune responses must balance between pathogen control and tissue damage. Thus, Mtb’simmune evasion mechanisms pose a significant challenge for vaccine development and therapeutic intervention. Understanding these interactions is critical for uncovering novel strategies against Mtb infection and improving public health outcomes.
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| format | Article |
| id | doaj-art-1ac781678dbf42f99321465d0d8fbf0a |
| institution | Kabale University |
| issn | 2817-5344 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | York University |
| record_format | Article |
| series | Canadian Journal for the Academic Mind |
| spelling | doaj-art-1ac781678dbf42f99321465d0d8fbf0a2025-08-20T03:52:52ZengYork UniversityCanadian Journal for the Academic Mind2817-53442025-05-012210.25071/2817-5344/99Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium TuberculosisEden Sedarous0https://orcid.org/0009-0002-0886-7971Dima Traboulsi1https://orcid.org/0009-0004-4656-6314Heeral Dodhia2https://orcid.org/0009-0004-5236-2393Katey Kwan3https://orcid.org/0009-0002-9589-8185Suky Zheng4https://orcid.org/0009-0008-4257-4578Venice Co5https://orcid.org/0009-0005-2813-5147Department of Kinesiology, McMaster UniversitySchool of Interdisciplinary Science, McMaster UniversitySchool of Interdisciplinary Science, McMaster UniversitySchool of Interdisciplinary Science, McMaster UniversityDepartment of Biochemistry and Biomedical Sciences, McMaster UniversitySchool of Interdisciplinary Science, McMaster UniversityThis review examines the complex interactions between Mycobacterium tuberculosis and host immunity, with a focus on Mtb and immune evasion. Upon inhalation, Mtb infects alveolar macrophages, inhibiting phagosome-lysosome fusion to survive. Dendritic cells are later activated, driving CD4+ T cell differentiation and IFN-γ release to enhance macrophage bactericidal activity. Mtb may be sequestered in granulomas, which contain the infection but facilitates Mtbpersistence during latency. Further, cytotoxic T lymphocytes eliminate infected cells, while regulatory T cells modulate immunity. Overall, host immune responses must balance between pathogen control and tissue damage. Thus, Mtb’simmune evasion mechanisms pose a significant challenge for vaccine development and therapeutic intervention. Understanding these interactions is critical for uncovering novel strategies against Mtb infection and improving public health outcomes. https://cjam.journals.yorku.ca/index.php/default/article/view/99Mycobacterium tuberculosisTuberculosisInnate immunityAdaptive immunityHost-pathogen interactionImmune evasion |
| spellingShingle | Eden Sedarous Dima Traboulsi Heeral Dodhia Katey Kwan Suky Zheng Venice Co Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium Tuberculosis Canadian Journal for the Academic Mind Mycobacterium tuberculosis Tuberculosis Innate immunity Adaptive immunity Host-pathogen interaction Immune evasion |
| title | Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium Tuberculosis |
| title_full | Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium Tuberculosis |
| title_fullStr | Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium Tuberculosis |
| title_full_unstemmed | Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium Tuberculosis |
| title_short | Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium Tuberculosis |
| title_sort | exploring the crossroads of innate and adaptive immunity against mycobacterium tuberculosis |
| topic | Mycobacterium tuberculosis Tuberculosis Innate immunity Adaptive immunity Host-pathogen interaction Immune evasion |
| url | https://cjam.journals.yorku.ca/index.php/default/article/view/99 |
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