Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium Tuberculosis
This review examines the complex interactions between Mycobacterium tuberculosis and host immunity, with a focus on Mtb and immune evasion. Upon inhalation, Mtb infects alveolar macrophages, inhibiting phagosome-lysosome fusion to survive. Dendritic cells are later activated, driving CD4+ T cell dif...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
York University
2025-05-01
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| Series: | Canadian Journal for the Academic Mind |
| Subjects: | |
| Online Access: | https://cjam.journals.yorku.ca/index.php/default/article/view/99 |
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| Summary: | This review examines the complex interactions between Mycobacterium tuberculosis and host immunity, with a focus on Mtb and immune evasion. Upon inhalation, Mtb infects alveolar macrophages, inhibiting phagosome-lysosome fusion to survive. Dendritic cells are later activated, driving CD4+ T cell differentiation and IFN-γ release to enhance macrophage bactericidal activity. Mtb may be sequestered in granulomas, which contain the infection but facilitates Mtbpersistence during latency. Further, cytotoxic T lymphocytes eliminate infected cells, while regulatory T cells modulate immunity. Overall, host immune responses must balance between pathogen control and tissue damage. Thus, Mtb’simmune evasion mechanisms pose a significant challenge for vaccine development and therapeutic intervention. Understanding these interactions is critical for uncovering novel strategies against Mtb infection and improving public health outcomes.
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| ISSN: | 2817-5344 |