Pregnancy and Pituitary Diseases

Pregnancy is a period in which the anatomy and physiology of the pituitary gland change significantly. Normal pituitary gland functions are necessary for fertility and the continuation of pregnancy. The presence of a pituitary disease requires management with a multidisciplinary approach to protect...

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Main Authors: Emre Urhan, Züleyha Karaca
Format: Article
Language:English
Published: AVES 2024-04-01
Series:Endocrinology Research and Practice
Online Access:https://endocrinolrespract.org/en/pregnancy-and-pituitary-diseases-131206
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author Emre Urhan
Züleyha Karaca
author_facet Emre Urhan
Züleyha Karaca
author_sort Emre Urhan
collection DOAJ
description Pregnancy is a period in which the anatomy and physiology of the pituitary gland change significantly. Normal pituitary gland functions are necessary for fertility and the continuation of pregnancy. The presence of a pituitary disease requires management with a multidisciplinary approach to protect the health of the mother and fetus, and it is recommended that these patients become pregnant in a planned manner. Treatment should be considered before pregnancy for pituitary adenomas with a risk of growth. Non-contrast magnetic resonance imaging (MRI) may be performed safely during pregnancy, but the ideal approach is to postpone the MRI until after the birth if possible, and if it is not possible, to take it without contrast. If there are no signs of compression in pituitary adenomas, no treatment is necessary during pregnancy. However, due to increased fetal and maternal morbidity and mortality in Cushing’s disease, treatment is necessary even if there is no compression. In the presence of compression findings, dopamine agonists can be used in all types of pituitary adenomas. Surgery may be performed in the second trimester for pituitary adenomas that cause compression unresponsive to medical treatment and for Cushing’s disease. In pregnant women with pituitary insufficiency, replacement doses should be adjusted according to the gestational week. The diagnosis and treatment of pituitary diseases in this period is more complex and specific than in the nonpregnant period and require a multidisciplinary approach.
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spelling doaj-art-1a8f70ebf694450bb7619c543e44ce402024-12-02T06:25:28ZengAVESEndocrinology Research and Practice2822-61352024-04-0128212112910.5152/erp.2024.23291Pregnancy and Pituitary DiseasesEmre Urhan0Züleyha Karaca1Department of Endocrinology, Erciyes University Faculty of Medicine, Kayseri, TurkeyDepartment of Endocrinology, Erciyes University Faculty of Medicine, Kayseri, TurkeyPregnancy is a period in which the anatomy and physiology of the pituitary gland change significantly. Normal pituitary gland functions are necessary for fertility and the continuation of pregnancy. The presence of a pituitary disease requires management with a multidisciplinary approach to protect the health of the mother and fetus, and it is recommended that these patients become pregnant in a planned manner. Treatment should be considered before pregnancy for pituitary adenomas with a risk of growth. Non-contrast magnetic resonance imaging (MRI) may be performed safely during pregnancy, but the ideal approach is to postpone the MRI until after the birth if possible, and if it is not possible, to take it without contrast. If there are no signs of compression in pituitary adenomas, no treatment is necessary during pregnancy. However, due to increased fetal and maternal morbidity and mortality in Cushing’s disease, treatment is necessary even if there is no compression. In the presence of compression findings, dopamine agonists can be used in all types of pituitary adenomas. Surgery may be performed in the second trimester for pituitary adenomas that cause compression unresponsive to medical treatment and for Cushing’s disease. In pregnant women with pituitary insufficiency, replacement doses should be adjusted according to the gestational week. The diagnosis and treatment of pituitary diseases in this period is more complex and specific than in the nonpregnant period and require a multidisciplinary approach.https://endocrinolrespract.org/en/pregnancy-and-pituitary-diseases-131206
spellingShingle Emre Urhan
Züleyha Karaca
Pregnancy and Pituitary Diseases
Endocrinology Research and Practice
title Pregnancy and Pituitary Diseases
title_full Pregnancy and Pituitary Diseases
title_fullStr Pregnancy and Pituitary Diseases
title_full_unstemmed Pregnancy and Pituitary Diseases
title_short Pregnancy and Pituitary Diseases
title_sort pregnancy and pituitary diseases
url https://endocrinolrespract.org/en/pregnancy-and-pituitary-diseases-131206
work_keys_str_mv AT emreurhan pregnancyandpituitarydiseases
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