Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets
Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows du...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1463707/full |
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| author | Xintao Wang Xintao Wang Tingting Fang Tingting Fang Daiwen Chen Daiwen Chen Junning Pu Junning Pu Gang Tian Gang Tian Jun He Jun He Ping Zheng Ping Zheng Xiangbing Mao Xiangbing Mao Aimin Wu Aimin Wu Bing Yu Bing Yu |
| author_facet | Xintao Wang Xintao Wang Tingting Fang Tingting Fang Daiwen Chen Daiwen Chen Junning Pu Junning Pu Gang Tian Gang Tian Jun He Jun He Ping Zheng Ping Zheng Xiangbing Mao Xiangbing Mao Aimin Wu Aimin Wu Bing Yu Bing Yu |
| author_sort | Xintao Wang |
| collection | DOAJ |
| description | Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows during late gestation and lactation on their productivity, placental function, and the intestinal health of IUGR piglets. From day (d) 85 of late gestation to d 21 of lactation, 30 sows were randomly divided into either a control group (basal diet) or a COS group (basal diet + 100 mg kg−1 COS). At d 21 of lactation, eight normal and eight IUGR littermates from eight litters belong to control sows, as well as eight IUGR littermates from COS sows, were selected for further analysis. The results showed a significant reduction in the number of stillbirths and mummies in COS groups (p < 0.05). Maternal dietary supplementation with COS also significantly up-regulated the expression levels of GLUT1, GLUT3, and VEGFA mRNA in the placenta of IUGR piglets compared to those in control group (p < 0.05). Furthermore, there was a significant decrease in MDA content and a significant increase in GSH content in the placenta of IUGR piglets from COS sows compared to those from control group (p < 0.05). Additionally, the expression levels of MUC2 and occludin mRNA as well as claudin1 protein significantly up-regulated in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (p < 0.05). Moreover, IL-10 mRNA expression level was significantly increased while MDA content was significantly reduced in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (p < 0.05). The results indicated that maternal dietary COS supplementation during late gestation effectively reduced the incidence of stillbirths and mummies, potentially linked to enhanced placental function, reduced oxidative stress, and improved immune status. Furthermore, maternal dietary COS supplementation exhibited positive impact on intestinal digestive and absorptive function, intestinal barrier integrity, intestinal antioxidant capacity and immune status in 21-day-old suckling IUGR piglets. |
| format | Article |
| id | doaj-art-1a6543dbf46c4d5bb4ce58df95d9abb0 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Veterinary Science |
| spelling | doaj-art-1a6543dbf46c4d5bb4ce58df95d9abb02024-11-13T15:43:48ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692024-11-011110.3389/fvets.2024.14637071463707Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling pigletsXintao Wang0Xintao Wang1Tingting Fang2Tingting Fang3Daiwen Chen4Daiwen Chen5Junning Pu6Junning Pu7Gang Tian8Gang Tian9Jun He10Jun He11Ping Zheng12Ping Zheng13Xiangbing Mao14Xiangbing Mao15Aimin Wu16Aimin Wu17Bing Yu18Bing Yu19Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease-Resistance Nutrition, China Ministry of Education, China Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Chengdu, ChinaMaternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study investigated the effect of COS as a dietary supplement for sows during late gestation and lactation on their productivity, placental function, and the intestinal health of IUGR piglets. From day (d) 85 of late gestation to d 21 of lactation, 30 sows were randomly divided into either a control group (basal diet) or a COS group (basal diet + 100 mg kg−1 COS). At d 21 of lactation, eight normal and eight IUGR littermates from eight litters belong to control sows, as well as eight IUGR littermates from COS sows, were selected for further analysis. The results showed a significant reduction in the number of stillbirths and mummies in COS groups (p < 0.05). Maternal dietary supplementation with COS also significantly up-regulated the expression levels of GLUT1, GLUT3, and VEGFA mRNA in the placenta of IUGR piglets compared to those in control group (p < 0.05). Furthermore, there was a significant decrease in MDA content and a significant increase in GSH content in the placenta of IUGR piglets from COS sows compared to those from control group (p < 0.05). Additionally, the expression levels of MUC2 and occludin mRNA as well as claudin1 protein significantly up-regulated in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (p < 0.05). Moreover, IL-10 mRNA expression level was significantly increased while MDA content was significantly reduced in the jejunum of 21-day-old IUGR piglets from COS sows group compared to those from control group (p < 0.05). The results indicated that maternal dietary COS supplementation during late gestation effectively reduced the incidence of stillbirths and mummies, potentially linked to enhanced placental function, reduced oxidative stress, and improved immune status. Furthermore, maternal dietary COS supplementation exhibited positive impact on intestinal digestive and absorptive function, intestinal barrier integrity, intestinal antioxidant capacity and immune status in 21-day-old suckling IUGR piglets.https://www.frontiersin.org/articles/10.3389/fvets.2024.1463707/fullchitosan oligosaccharideintrauterine growth retardationsowspigletsplacentaintestine |
| spellingShingle | Xintao Wang Xintao Wang Tingting Fang Tingting Fang Daiwen Chen Daiwen Chen Junning Pu Junning Pu Gang Tian Gang Tian Jun He Jun He Ping Zheng Ping Zheng Xiangbing Mao Xiangbing Mao Aimin Wu Aimin Wu Bing Yu Bing Yu Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets Frontiers in Veterinary Science chitosan oligosaccharide intrauterine growth retardation sows piglets placenta intestine |
| title | Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets |
| title_full | Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets |
| title_fullStr | Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets |
| title_full_unstemmed | Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets |
| title_short | Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets |
| title_sort | maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21 day old iugr suckling piglets |
| topic | chitosan oligosaccharide intrauterine growth retardation sows piglets placenta intestine |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1463707/full |
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