Repeated inhalation of GM-CSF by nonhuman primates induces bronchus-associated lymphoid tissue along the lower respiratory tract

Repeated inhalation of GM-CSF by nonhuman primates induces bronchus-associated lymphoid tissue along the lower respiratory tract

Abstract Background Repeated inhalation of granulocyte-macrophage colony-stimulating factor (GM-CSF) was recently approved in Japan as a treatment for autoimmune pulmonary alveolar proteinosis. However, the detailed physiological and pathological effects of repeated inhalation in the long term, espe...

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Bibliographic Details
Main Authors: Ryushi Tazawa, Riuko Ohashi, Nobutaka Kitamura, Takahiro Tanaka, Kazuhide Nakagaki, Sachiko Yuki, Atsushi Fujiwara, Koh Nakata
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Respiratory Research
Subjects:
Inhalation
GM-CSF
Autoimmune pulmonary alveolar proteinosis
Bronchus-associated lymphoid tissue
Cynomolgus monkey
Online Access:https://doi.org/10.1186/s12931-024-03003-w
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