Developmental alterations of indirect-pathway medium spiny neurons in mouse models of Huntington's disease

Developmental alterations of indirect-pathway medium spiny neurons in mouse models of Huntington's disease

Huntington's disease (HD) is a complex neurodegenerative disorder with cognitive and motor symptoms that typically manifest in adulthood. However, embryonic brain development impairments leading to cortical defects in HD mutation carriers has been shown recently supporting a neurodevelopmental...

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Bibliographic Details
Main Authors: Margaux Lebouc, Léa Bonamy, Thibault Dhellemmes, Jakob Scharnholz, Quentin Richard, Gilles Courtand, Alexandre Brochard, Frédéric Martins, Marc Landry, Jérôme Baufreton, Maurice Garret
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Neurobiology of Disease
Subjects:
Striatal development
Huntingtin
Electrophysiology
Neuronal excitability
Glutamatergic transmission
Neuronal morphology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000907
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