Green-synthesised silver nanoparticles: antibacterial activity and alternative mechanisms of action to combat multidrug-resistant bacterial pathogens: a systematic literature review
Antimicrobial resistance (AMR) is the top global public health and development threat. It has led to 4·95 million deaths associated with bacterial AMR in 2019, including 1·27 million deaths attributable to bacterial AMR. In addition to causing death and disability, it is projected that by 2030, the...
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Taylor & Francis Group
2024-12-01
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| Series: | Green Chemistry Letters and Reviews |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/17518253.2024.2412601 |
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| author | Abayeneh Girma Getachew Alamnie Tigabu Bekele Gedefaw Mebratie Bawoke Mekuye Birhanu Abera Dereba Workineh Abay Tabor Debela Jufar |
| author_facet | Abayeneh Girma Getachew Alamnie Tigabu Bekele Gedefaw Mebratie Bawoke Mekuye Birhanu Abera Dereba Workineh Abay Tabor Debela Jufar |
| author_sort | Abayeneh Girma |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) is the top global public health and development threat. It has led to 4·95 million deaths associated with bacterial AMR in 2019, including 1·27 million deaths attributable to bacterial AMR. In addition to causing death and disability, it is projected that by 2030, the annual gross domestic product (GDP) losses due to AMR could range from US$1 trillion to US$3.4 trillion. In the current study, bio-capped silver nanoparticles (AgNPs) showed significant antibacterial activities against both gram-positive and gram-negative MDR bacterial pathogens. 2.50 μg/ml to 100 mg/ml and 3.8 μg/ml to 2.5 mg/ml were the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of AgNPs, while the zone of inhibition (ZOI) was 4 to 25 mm. Particle size, shape, type of capping or stabilizing agent, surface charge, pH, exposure time, concentration, and bacterial type affect the antibacterial activities of AgNPs. Cell wall and membrane damage, destruction of biomolecules (lipids, proteins, and DNA), disruption of the electron transport chain, and proton motive force are mechanisms of action of AgNPs. In general, green-synthesised AgNPs from plants and bacteria (synergistic effect between AgNPs and natural compounds) displayed significant antibacterial activity against a wide range of Gram-positive and Gram-negative MDR bacteria. |
| format | Article |
| id | doaj-art-1a41353f19fc4089b16bd527005d6b8c |
| institution | Kabale University |
| issn | 1751-8253 1751-7192 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj-art-1a41353f19fc4089b16bd527005d6b8c2024-12-06T01:41:30ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922024-12-0117110.1080/17518253.2024.2412601Green-synthesised silver nanoparticles: antibacterial activity and alternative mechanisms of action to combat multidrug-resistant bacterial pathogens: a systematic literature reviewAbayeneh Girma0Getachew Alamnie1Tigabu Bekele2Gedefaw Mebratie3Bawoke Mekuye4Birhanu Abera5Dereba Workineh6Abay Tabor7Debela Jufar8Department of Biology, College of Natural and Computational Science, Mekdela Amba University, Tulu Awuliya, EthiopiaDepartment of Biology, College of Natural and Computational Science, Mekdela Amba University, Tulu Awuliya, EthiopiaDepartment of Chemistry, College of Natural and Computational Science, Mekdela Amba University, Tulu Awuliya, EthiopiaDepartment of Physics, College of Natural and Computational Science, Mekdela Amba University, Tulu Awuliya, EthiopiaDepartment of Physics, College of Natural and Computational Science, Mekdela Amba University, Tulu Awuliya, EthiopiaDepartment of Physics, College of Natural and Computational Science, Injibara University, Injibara, EthiopiaDepartment of Forensic Science, College of Crime Investigation and Forensic Science, Ethiopian Police University, Sendafa, EthiopiaDepartment of Biology, College of Natural and Computational Science, Mizan-Tepi University, Tepi, EthiopiaDepartment of Chemistry, College of Natural and Computational Science, Mizan-Tepi University, Tepi, EthiopiaAntimicrobial resistance (AMR) is the top global public health and development threat. It has led to 4·95 million deaths associated with bacterial AMR in 2019, including 1·27 million deaths attributable to bacterial AMR. In addition to causing death and disability, it is projected that by 2030, the annual gross domestic product (GDP) losses due to AMR could range from US$1 trillion to US$3.4 trillion. In the current study, bio-capped silver nanoparticles (AgNPs) showed significant antibacterial activities against both gram-positive and gram-negative MDR bacterial pathogens. 2.50 μg/ml to 100 mg/ml and 3.8 μg/ml to 2.5 mg/ml were the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of AgNPs, while the zone of inhibition (ZOI) was 4 to 25 mm. Particle size, shape, type of capping or stabilizing agent, surface charge, pH, exposure time, concentration, and bacterial type affect the antibacterial activities of AgNPs. Cell wall and membrane damage, destruction of biomolecules (lipids, proteins, and DNA), disruption of the electron transport chain, and proton motive force are mechanisms of action of AgNPs. In general, green-synthesised AgNPs from plants and bacteria (synergistic effect between AgNPs and natural compounds) displayed significant antibacterial activity against a wide range of Gram-positive and Gram-negative MDR bacteria.https://www.tandfonline.com/doi/10.1080/17518253.2024.2412601Silver nanoparticlesantibacterial activitymultidrug-resistant bacteriagreen synthesismechanisms |
| spellingShingle | Abayeneh Girma Getachew Alamnie Tigabu Bekele Gedefaw Mebratie Bawoke Mekuye Birhanu Abera Dereba Workineh Abay Tabor Debela Jufar Green-synthesised silver nanoparticles: antibacterial activity and alternative mechanisms of action to combat multidrug-resistant bacterial pathogens: a systematic literature review Green Chemistry Letters and Reviews Silver nanoparticles antibacterial activity multidrug-resistant bacteria green synthesis mechanisms |
| title | Green-synthesised silver nanoparticles: antibacterial activity and alternative mechanisms of action to combat multidrug-resistant bacterial pathogens: a systematic literature review |
| title_full | Green-synthesised silver nanoparticles: antibacterial activity and alternative mechanisms of action to combat multidrug-resistant bacterial pathogens: a systematic literature review |
| title_fullStr | Green-synthesised silver nanoparticles: antibacterial activity and alternative mechanisms of action to combat multidrug-resistant bacterial pathogens: a systematic literature review |
| title_full_unstemmed | Green-synthesised silver nanoparticles: antibacterial activity and alternative mechanisms of action to combat multidrug-resistant bacterial pathogens: a systematic literature review |
| title_short | Green-synthesised silver nanoparticles: antibacterial activity and alternative mechanisms of action to combat multidrug-resistant bacterial pathogens: a systematic literature review |
| title_sort | green synthesised silver nanoparticles antibacterial activity and alternative mechanisms of action to combat multidrug resistant bacterial pathogens a systematic literature review |
| topic | Silver nanoparticles antibacterial activity multidrug-resistant bacteria green synthesis mechanisms |
| url | https://www.tandfonline.com/doi/10.1080/17518253.2024.2412601 |
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