Optimization of a sensitive and reliable UPLC-MS/MS method to simultaneously quantify almonertinib and HAS-719 and its application to study the interaction with nicardipine

Optimization of a sensitive and reliable UPLC-MS/MS method to simultaneously quantify almonertinib and HAS-719 and its application to study the interaction with nicardipine

Context Almonertinib is primarily metabolized by CYP3A4, so it could interact with a variety of drugs metabolized by CYP3A4, leading to the changes of systemic exposure.Objective For the purpose of this experiment, an ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) assa...

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Bibliographic Details
Main Authors: Dongxin Chen, Jie Chen, Yuxin Shen, Xiaohai Chen, Hailun Xia, Ya-nan Liu, Ren-ai Xu
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Pharmaceutical Biology
Subjects:
Almonertinib
HAS-719
nicardipine
UPLC-MS/MS
rat plasma
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2024.2425648
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