Spatial transcriptomics in focal cortical dysplasia type IIb

Spatial transcriptomics in focal cortical dysplasia type IIb

Abstract Focal cortical dysplasia (FCD) type IIb (FCD IIb) is an epileptogenic malformation of the neocortex that is characterized by cortical dyslamination, dysmorphic neurons (DNs) and balloon cells (BCs). Approximately 30–60% of lesions are associated with brain somatic mutations in the mTOR path...

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Bibliographic Details
Main Authors: Yujiao Wang, Yihe Wang, Linai Guo, Chunhao Shen, Yongjuan Fu, Penghu Wei, Yongzhi Shan, Qian Wu, Yue-Shan Piao, Guoguang Zhao
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Acta Neuropathologica Communications
Subjects:
Focal cortical dysplasia type II
Spatial transcriptomics
Regulation of membrane potential
Complement activation
Inflammatory response
Drug-resistant epilepsy
Online Access:https://doi.org/10.1186/s40478-024-01897-7
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