RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis

RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis

Sepsis is caused by systemic infection and is a major health concern as it is the primary cause of death from infection. It is the leading cause of mortality worldwide and there are no specific effective treatments for sepsis. Gene deletion of the neutral solute channel Aquaporin 9 (AQP9) normalizes...

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Bibliographic Details
Main Authors: Shireen Mohammad, Caroline E. O’Riordan, Chiara Verra, Eleonora Aimaretti, Gustavo Ferreira Alves, Klaus Dreisch, Johan Evenäs, Patrizia Gena, Angela Tesse, Michael Rützler, Massimo Collino, Giuseppe Calamita, Christoph Thiemermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
aquaporin (AQP)
sepsis
cecal ligation and puncture
inflammation
multiple organ failure
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.900906/full
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