Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism
Background: The thyroid gland is a bilobed endocrine gland that secretes two vital hormones: thyroxine (T4) and triiodothyronine (T3). The production and release of these hormones are regulated by the thyroid-stimulating hormone (TSH) from the pituitary gland. Iron is an essential element for the no...
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Jaypee Brothers Medical Publisher
2024-08-01
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| Series: | Indian Journal of Medical Biochemistry |
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| Online Access: | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0239 |
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| author | Vartika Saini Sunny Chopra Jaspinder Kaur Maninder Kaur |
| author_facet | Vartika Saini Sunny Chopra Jaspinder Kaur Maninder Kaur |
| author_sort | Vartika Saini |
| collection | DOAJ |
| description | Background: The thyroid gland is a bilobed endocrine gland that secretes two vital hormones: thyroxine (T4) and triiodothyronine (T3). The production and release of these hormones are regulated by the thyroid-stimulating hormone (TSH) from the pituitary gland.
Iron is an essential element for the normal functioning of the thyroid gland. In the body, iron is stored in the form of ferritin, an intracellular protein. The aim of the present study was to evaluate the serum ferritin levels in patients with hypothyroidism.
Materials and methods: This case-control study was conducted on 100 lab-diagnosed cases based on the thyroid profile. About 50 healthy controls were included in the study. Thyroid profile which includes estimation of serum T3, T4, and TSH was done. Serum ferritin levels were also estimated in both cases and controls.
Results: The mean ± SD value of serum TSH levels in study group and control group was 14.45 ± 12.96 µIU/mL and 1.27 ± 1.05 µIU/mL, respectively. The mean ± SD of Serum ferritin in study group and control group was 9.95 ± 6.36 ng/mL and 149.35 ± 103.16 ng/mL, respectively. Serum ferritin and TSH shows significant (<i>p</i>-value ≤ 0.001). A significant negative correlation was found between TSH and serum ferritin in hypothyroid patients.
Conclusion: This suggests that hypothyroid patients had higher levels of TSH and lower levels of serum ferritin compared to the control group, and that there is a negative correlation between TSH and serum ferritin in hypothyroid patients. Hence, the estimation of serum ferritin concentration among hypothyroid patients could be useful in the evaluation of thyroid hormone status. |
| format | Article |
| id | doaj-art-19f71d00ab204cfa8c9d8f7d237fdeff |
| institution | Kabale University |
| issn | 2456-5164 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Medical Biochemistry |
| spelling | doaj-art-19f71d00ab204cfa8c9d8f7d237fdeff2025-01-03T07:49:51ZengJaypee Brothers Medical PublisherIndian Journal of Medical Biochemistry2456-51642024-08-0128362010.5005/jp-journals-10054-02391Evaluation of Serum Ferritin Levels in Patients of HypothyroidismVartika Saini0Sunny Chopra1Jaspinder Kaur2Maninder Kaur3Department of Biochemistry, Government Medical College, Patiala, Punjab, IndiaDepartment of Biochemistry, Government Medical College, Patiala, Punjab, IndiaDepartment of Biochemistry, Government Medical College, Patiala, Punjab, IndiaManinder Kaur, Department of Biochemistry, Government Medical College, Patiala, Punjab, India, Phone: +91 9815904935Background: The thyroid gland is a bilobed endocrine gland that secretes two vital hormones: thyroxine (T4) and triiodothyronine (T3). The production and release of these hormones are regulated by the thyroid-stimulating hormone (TSH) from the pituitary gland. Iron is an essential element for the normal functioning of the thyroid gland. In the body, iron is stored in the form of ferritin, an intracellular protein. The aim of the present study was to evaluate the serum ferritin levels in patients with hypothyroidism. Materials and methods: This case-control study was conducted on 100 lab-diagnosed cases based on the thyroid profile. About 50 healthy controls were included in the study. Thyroid profile which includes estimation of serum T3, T4, and TSH was done. Serum ferritin levels were also estimated in both cases and controls. Results: The mean ± SD value of serum TSH levels in study group and control group was 14.45 ± 12.96 µIU/mL and 1.27 ± 1.05 µIU/mL, respectively. The mean ± SD of Serum ferritin in study group and control group was 9.95 ± 6.36 ng/mL and 149.35 ± 103.16 ng/mL, respectively. Serum ferritin and TSH shows significant (<i>p</i>-value ≤ 0.001). A significant negative correlation was found between TSH and serum ferritin in hypothyroid patients. Conclusion: This suggests that hypothyroid patients had higher levels of TSH and lower levels of serum ferritin compared to the control group, and that there is a negative correlation between TSH and serum ferritin in hypothyroid patients. Hence, the estimation of serum ferritin concentration among hypothyroid patients could be useful in the evaluation of thyroid hormone status.https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0239enzyme linked immunosorbent assayhypothyroidserum ferritinthyroid peroxidasethyroid-stimulating hormonethyroxinetriiodothyronine |
| spellingShingle | Vartika Saini Sunny Chopra Jaspinder Kaur Maninder Kaur Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism Indian Journal of Medical Biochemistry enzyme linked immunosorbent assay hypothyroid serum ferritin thyroid peroxidase thyroid-stimulating hormone thyroxine triiodothyronine |
| title | Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism |
| title_full | Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism |
| title_fullStr | Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism |
| title_full_unstemmed | Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism |
| title_short | Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism |
| title_sort | evaluation of serum ferritin levels in patients of hypothyroidism |
| topic | enzyme linked immunosorbent assay hypothyroid serum ferritin thyroid peroxidase thyroid-stimulating hormone thyroxine triiodothyronine |
| url | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0239 |
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