Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases
Leprosy is one of the most common diseases of the peripheral nerves. In some cases there is only neural involvement without skin changes (neuritic form). The neuropathy has often a distal stocking and glove distribution with thermal and pinprick anesthesia and preservation of proprioception. There i...
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| Language: | English |
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Thieme Revinter Publicações
2003-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000400003&tlng=en |
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| author | Marcos R.G. de Freitas Osvaldo J.M. Nascimento Ernestina A.M. Quaglino Andréia Oliveira Myrian D. Hahn |
| author_facet | Marcos R.G. de Freitas Osvaldo J.M. Nascimento Ernestina A.M. Quaglino Andréia Oliveira Myrian D. Hahn |
| author_sort | Marcos R.G. de Freitas |
| collection | DOAJ |
| description | Leprosy is one of the most common diseases of the peripheral nerves. In some cases there is only neural involvement without skin changes (neuritic form). The neuropathy has often a distal stocking and glove distribution with thermal and pinprick anesthesia and preservation of proprioception. There is no weakness, the tendon reflexes may be preserved and sometimes the nerves are thickened. We reported 17 patients with a predominantly small-fiber polyneuropathy due to leprosy. All patients had distal temperature and pain anesthesia with different individual variations. The tendon reflexes were normal in seven patients and in eight there was thickening of the nerves. The nerve conduction was normal in three patients. Sural nerve biopsy consisted of: 1) inflammatory infiltrates, 2) vacuolated "foamy" cells, 3) fibrosis of endoneurium, perineurium, and epineurium, 4) partial or total loss of nerve fibers, 5) large number of bacilli. We concluded that in countries where leprosy is frequent, nerve biopsy is an obligatory procedure in patients with predominantly small-fiber polyneuropathy. |
| format | Article |
| id | doaj-art-19f3d44d239a4f09a8a4917880be77d8 |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2003-09-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-19f3d44d239a4f09a8a4917880be77d82025-08-20T03:54:21ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272003-09-01613A54254610.1590/S0004-282X2003000400003Small-fiber polyneuropathy in leprosy without skin changes: study of 17 casesMarcos R.G. de Freitas0Osvaldo J.M. Nascimento1Ernestina A.M. Quaglino2Andréia Oliveira3Myrian D. Hahn4Universidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseLeprosy is one of the most common diseases of the peripheral nerves. In some cases there is only neural involvement without skin changes (neuritic form). The neuropathy has often a distal stocking and glove distribution with thermal and pinprick anesthesia and preservation of proprioception. There is no weakness, the tendon reflexes may be preserved and sometimes the nerves are thickened. We reported 17 patients with a predominantly small-fiber polyneuropathy due to leprosy. All patients had distal temperature and pain anesthesia with different individual variations. The tendon reflexes were normal in seven patients and in eight there was thickening of the nerves. The nerve conduction was normal in three patients. Sural nerve biopsy consisted of: 1) inflammatory infiltrates, 2) vacuolated "foamy" cells, 3) fibrosis of endoneurium, perineurium, and epineurium, 4) partial or total loss of nerve fibers, 5) large number of bacilli. We concluded that in countries where leprosy is frequent, nerve biopsy is an obligatory procedure in patients with predominantly small-fiber polyneuropathy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000400003&tlng=enleprosypure neuritic leprosysmall-fiber polyneuropathyperipheral neuropathynerve biopsy |
| spellingShingle | Marcos R.G. de Freitas Osvaldo J.M. Nascimento Ernestina A.M. Quaglino Andréia Oliveira Myrian D. Hahn Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases Arquivos de Neuro-Psiquiatria leprosy pure neuritic leprosy small-fiber polyneuropathy peripheral neuropathy nerve biopsy |
| title | Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases |
| title_full | Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases |
| title_fullStr | Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases |
| title_full_unstemmed | Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases |
| title_short | Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases |
| title_sort | small fiber polyneuropathy in leprosy without skin changes study of 17 cases |
| topic | leprosy pure neuritic leprosy small-fiber polyneuropathy peripheral neuropathy nerve biopsy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000400003&tlng=en |
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