Impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive mice
The aim of the present study was to examine the antihypertensive effect of black soybean peptides (BSP) and investigate the role of these peptides in ameliorating hypertension-induced intestinal damage and modulating gut microbiota. The findings demonstrated that BSP could significantly reduce the b...
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Elsevier
2024-12-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462400611X |
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| author | Dawei Cheng Xinyu Huang Caihong Zhang Ben Shao Xueling Li Meiqing Li |
| author_facet | Dawei Cheng Xinyu Huang Caihong Zhang Ben Shao Xueling Li Meiqing Li |
| author_sort | Dawei Cheng |
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| description | The aim of the present study was to examine the antihypertensive effect of black soybean peptides (BSP) and investigate the role of these peptides in ameliorating hypertension-induced intestinal damage and modulating gut microbiota. The findings demonstrated that BSP could significantly reduce the blood pressure of mice with diet-induced hypertension (P < 0.001). Simultaneously, BSP effectively inhibited the production of pro-inflammatory factors (IL-17 and TNF-α) and increased the levels of an anti-inflammatory factor (IL-10) in the colon of mouse models of hypertension. Additionally, BSP up-regulated the gene expression of intestinal barrier factors ZO-1, Occludin, and MUC-2, and alleviated the hypertension-induced inflammatory infiltration of colon tissue. Furthermore, the peptides increased the levels of short-chain fatty acids (SCFAs) in the feces and up-regulated the protein expression of the SCFA receptor GPR41/43. The analysis of intestinal microbes showed that BSP could modulate the richness and diversity of the intestinal microbiota in mouse models of hypertension, increase the abundance of beneficial bacteria, decrease the abundance of harmful bacteria, and promote the homeostasis of the imbalanced intestinal microbiota. Notably, BSP exerted a significant protective effect against L-NAME-induced hypertension in mice, demonstrating good outcomes with respect to blood pressure regulation, intestinal protection, and intestinal microbiota balance. Therefore, BSP may ameliorate the harm caused by hypertension and could aid in the prevention of hypertension as a dietary intervention. |
| format | Article |
| id | doaj-art-19f2fa875bbd497dbe82e92a9838e39d |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-19f2fa875bbd497dbe82e92a9838e39d2024-12-14T06:30:21ZengElsevierJournal of Functional Foods1756-46462024-12-01123106608Impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive miceDawei Cheng0Xinyu Huang1Caihong Zhang2Ben Shao3Xueling Li4Meiqing Li5Anhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products, Anhui Agricultural University, Hefei 230036, China; College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei 230036, China; Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization, Ministry of Agriculture and Rural Affairs, Anhui Agricultural University, Hefei 230036, ChinaAnhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products, Anhui Agricultural University, Hefei 230036, China; College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei 230036, China; Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization, Ministry of Agriculture and Rural Affairs, Anhui Agricultural University, Hefei 230036, ChinaAnhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products, Anhui Agricultural University, Hefei 230036, China; College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei 230036, China; Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization, Ministry of Agriculture and Rural Affairs, Anhui Agricultural University, Hefei 230036, ChinaAnhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products, Anhui Agricultural University, Hefei 230036, China; College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei 230036, China; Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization, Ministry of Agriculture and Rural Affairs, Anhui Agricultural University, Hefei 230036, ChinaAnhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products, Anhui Agricultural University, Hefei 230036, China; College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei 230036, China; Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization, Ministry of Agriculture and Rural Affairs, Anhui Agricultural University, Hefei 230036, ChinaAnhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products, Anhui Agricultural University, Hefei 230036, China; College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei 230036, China; Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization, Ministry of Agriculture and Rural Affairs, Anhui Agricultural University, Hefei 230036, China; Corresponding author at: College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei 230036, China.The aim of the present study was to examine the antihypertensive effect of black soybean peptides (BSP) and investigate the role of these peptides in ameliorating hypertension-induced intestinal damage and modulating gut microbiota. The findings demonstrated that BSP could significantly reduce the blood pressure of mice with diet-induced hypertension (P < 0.001). Simultaneously, BSP effectively inhibited the production of pro-inflammatory factors (IL-17 and TNF-α) and increased the levels of an anti-inflammatory factor (IL-10) in the colon of mouse models of hypertension. Additionally, BSP up-regulated the gene expression of intestinal barrier factors ZO-1, Occludin, and MUC-2, and alleviated the hypertension-induced inflammatory infiltration of colon tissue. Furthermore, the peptides increased the levels of short-chain fatty acids (SCFAs) in the feces and up-regulated the protein expression of the SCFA receptor GPR41/43. The analysis of intestinal microbes showed that BSP could modulate the richness and diversity of the intestinal microbiota in mouse models of hypertension, increase the abundance of beneficial bacteria, decrease the abundance of harmful bacteria, and promote the homeostasis of the imbalanced intestinal microbiota. Notably, BSP exerted a significant protective effect against L-NAME-induced hypertension in mice, demonstrating good outcomes with respect to blood pressure regulation, intestinal protection, and intestinal microbiota balance. Therefore, BSP may ameliorate the harm caused by hypertension and could aid in the prevention of hypertension as a dietary intervention.http://www.sciencedirect.com/science/article/pii/S175646462400611XBlack soybean peptidesHypertensionGut microbiotaIntestinal inflammationPreventionIntervention |
| spellingShingle | Dawei Cheng Xinyu Huang Caihong Zhang Ben Shao Xueling Li Meiqing Li Impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive mice Journal of Functional Foods Black soybean peptides Hypertension Gut microbiota Intestinal inflammation Prevention Intervention |
| title | Impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive mice |
| title_full | Impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive mice |
| title_fullStr | Impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive mice |
| title_full_unstemmed | Impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive mice |
| title_short | Impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive mice |
| title_sort | impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive mice |
| topic | Black soybean peptides Hypertension Gut microbiota Intestinal inflammation Prevention Intervention |
| url | http://www.sciencedirect.com/science/article/pii/S175646462400611X |
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