Biopreservation and reversal of oxidative injury during blood storage by a novel curcumin-based gel formulation

Abstract Blood storage lesion induces cytosolic and membrane changes driven in part by hemoglobin (Hb) oxidation reactions within red blood cells (RBCs). A novel gel formulation containing the antioxidant curcuminoids in a biocompatible solvent system was used to deliver curcumin into RBCs. Incubati...

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Bibliographic Details
Main Authors: Wayne Hicks, Sirsendu Jana, Tigist Kassa, Richard Prince, Pedro Cabrales, Joel Friedman, Abdu I. Alayash
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-82943-1
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