Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects

Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects

Abstract Research into cancer treatment has been mainly focused on developing therapies to directly target cancer cells. Over the past decade, extensive studies have revealed critical roles of the tumour microenvironment (TME) in cancer initiation, progression, and drug resistance. Notably, cancer-a...

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Bibliographic Details
Main Authors: Zhipeng Cao, Sadia Quazi, Sakshi Arora, Laura D. Osellame, Ingrid J. Burvenich, Peter W. Janes, Andrew M. Scott
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Biomedical Science
Subjects:
Tumour microenvironment
Cancer-associated fibroblasts
Tumour stroma
Targeted therapy
Clinical trials
Online Access:https://doi.org/10.1186/s12929-024-01099-2
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