DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K/AKT signaling pathway

DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K/AKT signaling pathway

Abstract Background Sepsis-induced acute lung injury (ALI) is a clinical condition with high morbidity and mortality, and impaired endothelial function is the main pathological characteristic. As a member of DNA demethylases, ten-eleven translocation protein 2 (TET2) is involved in a variety of biol...

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Bibliographic Details
Main Authors: Hongxue Fu, Bin Gao, Xin Zhou, Yingting Hao, Chang Liu, Ailin Lan, Jingyi Tang, Fachun Zhou
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cellular & Molecular Biology Letters
Subjects:
TET2
5-hmC
Endothelial cell dysfunction
ITGA10
Sepsis-induced acute lung injury
Online Access:https://doi.org/10.1186/s11658-025-00739-1
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