Hydroxychloroquine-induced Sweet’s Syndrome: A Case Report and Literature Review
Sweet’s syndrome (or acute febrile dermatosis) is a neutrophilic dermatosis with a characteristic presentation encompassing specific clinical (fever and erythemato-violaceous oedematous papules, plaques and nodules), laboratory (neutrophilia and increased inflammatory markers), and histological (der...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Journals Sweden
2025-01-01
|
| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/41333 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553944628690944 |
|---|---|
| author | Gustavo Almeida-Silva Joana Antunes Inês Tribolet de Abreu Filipe Monteiro Pedro Vasconcelos Luís Soares-Almeida Paulo Filipe |
| author_facet | Gustavo Almeida-Silva Joana Antunes Inês Tribolet de Abreu Filipe Monteiro Pedro Vasconcelos Luís Soares-Almeida Paulo Filipe |
| author_sort | Gustavo Almeida-Silva |
| collection | DOAJ |
| description | Sweet’s syndrome (or acute febrile dermatosis) is a neutrophilic dermatosis with a characteristic presentation encompassing specific clinical (fever and erythemato-violaceous oedematous papules, plaques and nodules), laboratory (neutrophilia and increased inflammatory markers), and histological (dermal neutrophilic infiltrate without vasculitis) features. Its pathophysiology is poorly understood but there seems to be an auto-inflammatory component related to mutations in inflammasome genes. It has been subdivided into its classic form, malignancy-associated, and drug-induced, according to its aetiology. The condition usually responds rapidly to steroid therapy, but recurrences are common. This report presents an extremely rare case of hydroxychloroquine-induced Sweet’s syndrome, plus a review of the literature, which encompasses 3 previous cases of Sweet’s syndrome induced by hydroxychloroquine and 1 induced by chloroquine. Despite being relatively easy to diagnose, aetiological investigation poses challenges to the clinician, especially in the elderly population, as several confounding factors might be present. Further studies are necessary to shed light on the pathophysiology behind this entity, to further facilitate diagnostic workup and treatment strategies.
|
| format | Article |
| id | doaj-art-19c7697aa323432ab0207492f0abc381 |
| institution | Kabale University |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-19c7697aa323432ab0207492f0abc3812025-01-09T05:53:11ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-01-0110510.2340/actadv.v105.41333Hydroxychloroquine-induced Sweet’s Syndrome: A Case Report and Literature ReviewGustavo Almeida-Silva0https://orcid.org/0009-0000-0669-5366Joana Antunes1https://orcid.org/0000-0003-0221-7193Inês Tribolet de Abreu2https://orcid.org/0009-0008-4497-9763Filipe Monteiro3https://orcid.org/0009-0008-9950-1521Pedro Vasconcelos4Luís Soares-Almeida5https://orcid.org/0000-0003-4026-6105Paulo Filipe6Dermatology Department, Unidade Local de Saúde Santa Maria, Lisbon, PortugalDermatology Department, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, PortugalDermatology Department, Unidade Local de Saúde Santa Maria, Lisbon, PortugalDermatology Department, Unidade Local de Saúde Santa Maria, Lisbon, PortugalDermatology Department, Unidade Local de Saúde Santa Maria, Lisbon, PortugalDermatology Department, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, PortugalDermatology Department, Unidade Local de Saúde Santa Maria, Lisbon, Portugal; Dermatology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Dermatology Research Unit, Instituto de Medicina Molecular, University of Lisbon, Lisbon, PortugalSweet’s syndrome (or acute febrile dermatosis) is a neutrophilic dermatosis with a characteristic presentation encompassing specific clinical (fever and erythemato-violaceous oedematous papules, plaques and nodules), laboratory (neutrophilia and increased inflammatory markers), and histological (dermal neutrophilic infiltrate without vasculitis) features. Its pathophysiology is poorly understood but there seems to be an auto-inflammatory component related to mutations in inflammasome genes. It has been subdivided into its classic form, malignancy-associated, and drug-induced, according to its aetiology. The condition usually responds rapidly to steroid therapy, but recurrences are common. This report presents an extremely rare case of hydroxychloroquine-induced Sweet’s syndrome, plus a review of the literature, which encompasses 3 previous cases of Sweet’s syndrome induced by hydroxychloroquine and 1 induced by chloroquine. Despite being relatively easy to diagnose, aetiological investigation poses challenges to the clinician, especially in the elderly population, as several confounding factors might be present. Further studies are necessary to shed light on the pathophysiology behind this entity, to further facilitate diagnostic workup and treatment strategies. https://medicaljournalssweden.se/actadv/article/view/41333Sweet syndromeneutrophilic dermatoseshydroxychloroquinechloroquinedrug-induced |
| spellingShingle | Gustavo Almeida-Silva Joana Antunes Inês Tribolet de Abreu Filipe Monteiro Pedro Vasconcelos Luís Soares-Almeida Paulo Filipe Hydroxychloroquine-induced Sweet’s Syndrome: A Case Report and Literature Review Acta Dermato-Venereologica Sweet syndrome neutrophilic dermatoses hydroxychloroquine chloroquine drug-induced |
| title | Hydroxychloroquine-induced Sweet’s Syndrome: A Case Report and Literature Review |
| title_full | Hydroxychloroquine-induced Sweet’s Syndrome: A Case Report and Literature Review |
| title_fullStr | Hydroxychloroquine-induced Sweet’s Syndrome: A Case Report and Literature Review |
| title_full_unstemmed | Hydroxychloroquine-induced Sweet’s Syndrome: A Case Report and Literature Review |
| title_short | Hydroxychloroquine-induced Sweet’s Syndrome: A Case Report and Literature Review |
| title_sort | hydroxychloroquine induced sweet s syndrome a case report and literature review |
| topic | Sweet syndrome neutrophilic dermatoses hydroxychloroquine chloroquine drug-induced |
| url | https://medicaljournalssweden.se/actadv/article/view/41333 |
| work_keys_str_mv | AT gustavoalmeidasilva hydroxychloroquineinducedsweetssyndromeacasereportandliteraturereview AT joanaantunes hydroxychloroquineinducedsweetssyndromeacasereportandliteraturereview AT inestriboletdeabreu hydroxychloroquineinducedsweetssyndromeacasereportandliteraturereview AT filipemonteiro hydroxychloroquineinducedsweetssyndromeacasereportandliteraturereview AT pedrovasconcelos hydroxychloroquineinducedsweetssyndromeacasereportandliteraturereview AT luissoaresalmeida hydroxychloroquineinducedsweetssyndromeacasereportandliteraturereview AT paulofilipe hydroxychloroquineinducedsweetssyndromeacasereportandliteraturereview |