Endophytic fungi: nature’s solution for antimicrobial resistance and sustainable agriculture
The growing threat of antimicrobial resistance (AMR) has underlined the need for a sustained supply of novel antimicrobial agents. Endophyte microorganism that reside within plant tissues as symbionts have been the source of potential antimicrobial substances. However, many novel and potent antimicr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1461504/full |
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| author | Asiya Nazir Abdul R. Puthuveettil Fathima Hasnain Nadeem Hussain Khalid E. Hamed Nayla Munawar |
| author_facet | Asiya Nazir Abdul R. Puthuveettil Fathima Hasnain Nadeem Hussain Khalid E. Hamed Nayla Munawar |
| author_sort | Asiya Nazir |
| collection | DOAJ |
| description | The growing threat of antimicrobial resistance (AMR) has underlined the need for a sustained supply of novel antimicrobial agents. Endophyte microorganism that reside within plant tissues as symbionts have been the source of potential antimicrobial substances. However, many novel and potent antimicrobials are yet to be discovered from these endophytes. The present study investigates the potential of endophytic fungi as a source of novel bioactive chemicals with antibacterial capabilities. These fungi synthesize secondary metabolites such as polyketides and peptides via polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways. Notable substances, like prenylated indole alkaloids and fumaric acid, have shown promising antibacterial and antifungal properties against multidrug-resistant infectious agents. This review also emphasizes the symbiotic link between endophytes and their host plants, which is critical for secondary metabolite production. The study focuses on the significance of isolation methods for endophytes and proposes their use in for sustainable agriculture, bioremediation, and medicine. Future research combining endophytic biodiversity analysis with next-generation sequencing (NGS) and nanotechnology could provide novel techniques for combating AMR and contributing to sustainability across multiple industries. |
| format | Article |
| id | doaj-art-19c2a3f2e9924d89b3af9e1897a8c790 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-19c2a3f2e9924d89b3af9e1897a8c7902024-12-12T06:18:39ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-12-011510.3389/fmicb.2024.14615041461504Endophytic fungi: nature’s solution for antimicrobial resistance and sustainable agricultureAsiya Nazir0Abdul R. Puthuveettil1Fathima Hasnain Nadeem Hussain2Khalid E. Hamed3Nayla Munawar4College of Engineering, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab EmiratesCollege of Engineering, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab EmiratesCollege of Engineering, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab EmiratesDepartment of Plant Protection, College of Agriculture and Food, Qassim University, Buraydah, Saudi ArabiaCollege of Engineering, Abu Dhabi University, Abu Dhabi, United Arab EmiratesThe growing threat of antimicrobial resistance (AMR) has underlined the need for a sustained supply of novel antimicrobial agents. Endophyte microorganism that reside within plant tissues as symbionts have been the source of potential antimicrobial substances. However, many novel and potent antimicrobials are yet to be discovered from these endophytes. The present study investigates the potential of endophytic fungi as a source of novel bioactive chemicals with antibacterial capabilities. These fungi synthesize secondary metabolites such as polyketides and peptides via polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways. Notable substances, like prenylated indole alkaloids and fumaric acid, have shown promising antibacterial and antifungal properties against multidrug-resistant infectious agents. This review also emphasizes the symbiotic link between endophytes and their host plants, which is critical for secondary metabolite production. The study focuses on the significance of isolation methods for endophytes and proposes their use in for sustainable agriculture, bioremediation, and medicine. Future research combining endophytic biodiversity analysis with next-generation sequencing (NGS) and nanotechnology could provide novel techniques for combating AMR and contributing to sustainability across multiple industries.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1461504/fullantibacterial compounddrug resistanceendophytic fungigene activationnatural product regulation |
| spellingShingle | Asiya Nazir Abdul R. Puthuveettil Fathima Hasnain Nadeem Hussain Khalid E. Hamed Nayla Munawar Endophytic fungi: nature’s solution for antimicrobial resistance and sustainable agriculture Frontiers in Microbiology antibacterial compound drug resistance endophytic fungi gene activation natural product regulation |
| title | Endophytic fungi: nature’s solution for antimicrobial resistance and sustainable agriculture |
| title_full | Endophytic fungi: nature’s solution for antimicrobial resistance and sustainable agriculture |
| title_fullStr | Endophytic fungi: nature’s solution for antimicrobial resistance and sustainable agriculture |
| title_full_unstemmed | Endophytic fungi: nature’s solution for antimicrobial resistance and sustainable agriculture |
| title_short | Endophytic fungi: nature’s solution for antimicrobial resistance and sustainable agriculture |
| title_sort | endophytic fungi nature s solution for antimicrobial resistance and sustainable agriculture |
| topic | antibacterial compound drug resistance endophytic fungi gene activation natural product regulation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1461504/full |
| work_keys_str_mv | AT asiyanazir endophyticfunginaturessolutionforantimicrobialresistanceandsustainableagriculture AT abdulrputhuveettil endophyticfunginaturessolutionforantimicrobialresistanceandsustainableagriculture AT fathimahasnainnadeemhussain endophyticfunginaturessolutionforantimicrobialresistanceandsustainableagriculture AT khalidehamed endophyticfunginaturessolutionforantimicrobialresistanceandsustainableagriculture AT naylamunawar endophyticfunginaturessolutionforantimicrobialresistanceandsustainableagriculture |