Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes
Abstract Mesenchymal stem cells (MSCs) have shown a great potential role in treating liver injury. MSCs can promote liver regeneration by differentiating into hepatocytes, and can also secrete exosomes to participate in the repair of liver injury. Increasing evidence has shown that mesenchymal stem...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-024-04087-3 |
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| _version_ | 1846112754149097472 |
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| author | Changlong Hu Lin Wang |
| author_facet | Changlong Hu Lin Wang |
| author_sort | Changlong Hu |
| collection | DOAJ |
| description | Abstract Mesenchymal stem cells (MSCs) have shown a great potential role in treating liver injury. MSCs can promote liver regeneration by differentiating into hepatocytes, and can also secrete exosomes to participate in the repair of liver injury. Increasing evidence has shown that mesenchymal stem cell-derived exosomes (MSC-EXOs) play an important role in treating liver injury. In this review, the biogenesis and function of exosomes and the characteristics of MSC-EXOs were analyzed based on recent research results. MSC-EXOs are significant in liver injuries such as liver fibrosis, liver failure, hepatocellular carcinoma, oxidative stress, and lipid steatosis, and participate in the process of liver regeneration. |
| format | Article |
| id | doaj-art-19a9ce89824245c39191f5c79c7229fe |
| institution | Kabale University |
| issn | 1757-6512 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-19a9ce89824245c39191f5c79c7229fe2024-12-22T12:18:52ZengBMCStem Cell Research & Therapy1757-65122024-12-0115111610.1186/s13287-024-04087-3Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomesChanglong Hu0Lin Wang1Department of Hepatobiliary Surgery, Xijing Hospital, Air Force Military Medical UniversityDepartment of Hepatobiliary Surgery, Xijing Hospital, Air Force Military Medical UniversityAbstract Mesenchymal stem cells (MSCs) have shown a great potential role in treating liver injury. MSCs can promote liver regeneration by differentiating into hepatocytes, and can also secrete exosomes to participate in the repair of liver injury. Increasing evidence has shown that mesenchymal stem cell-derived exosomes (MSC-EXOs) play an important role in treating liver injury. In this review, the biogenesis and function of exosomes and the characteristics of MSC-EXOs were analyzed based on recent research results. MSC-EXOs are significant in liver injuries such as liver fibrosis, liver failure, hepatocellular carcinoma, oxidative stress, and lipid steatosis, and participate in the process of liver regeneration.https://doi.org/10.1186/s13287-024-04087-3Mesenchymal stem cellsExosomesLiver injuryLiver regeneration |
| spellingShingle | Changlong Hu Lin Wang Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes Stem Cell Research & Therapy Mesenchymal stem cells Exosomes Liver injury Liver regeneration |
| title | Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes |
| title_full | Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes |
| title_fullStr | Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes |
| title_full_unstemmed | Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes |
| title_short | Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes |
| title_sort | advances in the treatment of liver injury based on mesenchymal stem cell derived exosomes |
| topic | Mesenchymal stem cells Exosomes Liver injury Liver regeneration |
| url | https://doi.org/10.1186/s13287-024-04087-3 |
| work_keys_str_mv | AT changlonghu advancesinthetreatmentofliverinjurybasedonmesenchymalstemcellderivedexosomes AT linwang advancesinthetreatmentofliverinjurybasedonmesenchymalstemcellderivedexosomes |