The Influence of Cell Isolation and Culturing on Natriuretic Peptide Receptors in Aortic Vascular Smooth Muscle Cells

The Influence of Cell Isolation and Culturing on Natriuretic Peptide Receptors in Aortic Vascular Smooth Muscle Cells

Vascular smooth muscle cell (SMC) relaxation by guanylyl cyclases (GCs) and cGMP is mediated by NO and its receptor soluble GC (sGC) or natriuretic peptides (NPs) ANP/BNP and CNP with the receptors GC-A and GC-B, respectively. It is commonly accepted that cultured SMCs differ from those in intact ve...

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Bibliographic Details
Main Authors: Christine Rager, Tobias Klöpper, Sabine Tasch, Michael Raymond Whittaker, Betty Exintaris, Andrea Mietens, Ralf Middendorff
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
vascular smooth muscle cells
aorta
cGMP signaling
natriuretic peptides
nitric oxide
phenotype switch
Online Access:https://www.mdpi.com/2073-4409/14/1/51
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