Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential
Sepsis-induced acute lung injury (ALI) remains a leading cause of mortality in critically ill patients. Macrophages, key modulators of immune responses, play a dual role in both promoting and resolving inflammation. Exosomes, small extracellular vesicles released by various cells, carry bioactive mo...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1518008/full |
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| _version_ | 1841556844069257216 |
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| author | Kaiying Lv Qun Liang |
| author_facet | Kaiying Lv Qun Liang |
| author_sort | Kaiying Lv |
| collection | DOAJ |
| description | Sepsis-induced acute lung injury (ALI) remains a leading cause of mortality in critically ill patients. Macrophages, key modulators of immune responses, play a dual role in both promoting and resolving inflammation. Exosomes, small extracellular vesicles released by various cells, carry bioactive molecules that influence macrophage polarization and immune responses. Emerging researchers have identified exosomes as crucial mediators that modulate macrophage activity during sepsis-induced ALI. This review explores the role of exosomes in modulating macrophage functions, focusing on the cellular interactions within the lung microenvironment and their potential as therapeutic targets. It highlights the regulation of macrophages by exosomes derived from pathogenic germs, neutrophils, alveolar epithelial cells, and mesenchymal stromal cells. By understanding these mechanisms, it aims to uncover innovative therapeutic strategies for sepsis-induced ALI. |
| format | Article |
| id | doaj-art-192dae92ad20475fa004ddfe15b44746 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-192dae92ad20475fa004ddfe15b447462025-01-07T05:23:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15180081518008Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potentialKaiying Lv0Qun Liang1Graduate School, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Critical Care Medicine, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, ChinaSepsis-induced acute lung injury (ALI) remains a leading cause of mortality in critically ill patients. Macrophages, key modulators of immune responses, play a dual role in both promoting and resolving inflammation. Exosomes, small extracellular vesicles released by various cells, carry bioactive molecules that influence macrophage polarization and immune responses. Emerging researchers have identified exosomes as crucial mediators that modulate macrophage activity during sepsis-induced ALI. This review explores the role of exosomes in modulating macrophage functions, focusing on the cellular interactions within the lung microenvironment and their potential as therapeutic targets. It highlights the regulation of macrophages by exosomes derived from pathogenic germs, neutrophils, alveolar epithelial cells, and mesenchymal stromal cells. By understanding these mechanisms, it aims to uncover innovative therapeutic strategies for sepsis-induced ALI.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1518008/fullmacrophagessepsis-induced acute lung injuryexosomesinflammationtherapy abbreviations |
| spellingShingle | Kaiying Lv Qun Liang Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential Frontiers in Immunology macrophages sepsis-induced acute lung injury exosomes inflammation therapy abbreviations |
| title | Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential |
| title_full | Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential |
| title_fullStr | Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential |
| title_full_unstemmed | Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential |
| title_short | Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential |
| title_sort | macrophages in sepsis induced acute lung injury exosomal modulation and therapeutic potential |
| topic | macrophages sepsis-induced acute lung injury exosomes inflammation therapy abbreviations |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1518008/full |
| work_keys_str_mv | AT kaiyinglv macrophagesinsepsisinducedacutelunginjuryexosomalmodulationandtherapeuticpotential AT qunliang macrophagesinsepsisinducedacutelunginjuryexosomalmodulationandtherapeuticpotential |