Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancer
Immuno-oncological cancer management is shifting to neoadjuvant treatments. In patients with gastrointestinal cancers, particularly locally advanced rectal cancer, neoadjuvant chemoimmunotherapy often induce complete responses, hence avoiding surgical intervention. Recent clinical trials indicate th...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | OncoImmunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2024.2416558 |
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| _version_ | 1846142171956117504 |
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| author | Yan Wang Liwei Zhao Zhen Zhang Peng Liu |
| author_facet | Yan Wang Liwei Zhao Zhen Zhang Peng Liu |
| author_sort | Yan Wang |
| collection | DOAJ |
| description | Immuno-oncological cancer management is shifting to neoadjuvant treatments. In patients with gastrointestinal cancers, particularly locally advanced rectal cancer, neoadjuvant chemoimmunotherapy often induce complete responses, hence avoiding surgical intervention. Recent clinical trials indicate that combinations of oxaliplatin-based chemotherapy and PD-1/PD-L1-targeting immunotherapy can be safely administered before surgery with curative intent. |
| format | Article |
| id | doaj-art-18ec85d9401b497a93c1b96895318086 |
| institution | Kabale University |
| issn | 2162-402X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj-art-18ec85d9401b497a93c1b968953180862024-12-03T13:49:35ZengTaylor & Francis GroupOncoImmunology2162-402X2024-12-0113110.1080/2162402X.2024.2416558Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancerYan Wang0Liwei Zhao1Zhen Zhang2Peng Liu3Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaCentre de Recherche des Cordeliers, Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, FranceDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaCentre de Recherche des Cordeliers, Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, FranceImmuno-oncological cancer management is shifting to neoadjuvant treatments. In patients with gastrointestinal cancers, particularly locally advanced rectal cancer, neoadjuvant chemoimmunotherapy often induce complete responses, hence avoiding surgical intervention. Recent clinical trials indicate that combinations of oxaliplatin-based chemotherapy and PD-1/PD-L1-targeting immunotherapy can be safely administered before surgery with curative intent.https://www.tandfonline.com/doi/10.1080/2162402X.2024.2416558Cancer immunotherapyImmunogenic cell deathFc receptorImmune checkpoint inhibitorTotal neoadjuvant therapy |
| spellingShingle | Yan Wang Liwei Zhao Zhen Zhang Peng Liu Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancer OncoImmunology Cancer immunotherapy Immunogenic cell death Fc receptor Immune checkpoint inhibitor Total neoadjuvant therapy |
| title | Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancer |
| title_full | Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancer |
| title_fullStr | Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancer |
| title_full_unstemmed | Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancer |
| title_short | Immunogenic cell death inducers and PD-1 blockade as neoadjuvant therapy for rectal cancer |
| title_sort | immunogenic cell death inducers and pd 1 blockade as neoadjuvant therapy for rectal cancer |
| topic | Cancer immunotherapy Immunogenic cell death Fc receptor Immune checkpoint inhibitor Total neoadjuvant therapy |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2024.2416558 |
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