Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy
Abstract Helicobacter pylori (H. pylori) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along with the adverse effects caused by complicated medication protocols, has made the eradication of H. pylori a more formi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202408583 |
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| author | Xiaojing Yin Yongkang Lai Xinyuan Zhang Tingling Zhang Jing Tian Yiqi Du Zhaoshen Li Jie Gao |
| author_facet | Xiaojing Yin Yongkang Lai Xinyuan Zhang Tingling Zhang Jing Tian Yiqi Du Zhaoshen Li Jie Gao |
| author_sort | Xiaojing Yin |
| collection | DOAJ |
| description | Abstract Helicobacter pylori (H. pylori) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along with the adverse effects caused by complicated medication protocols, has made the eradication of H. pylori a more formidable challenge, necessitating alternative therapeutics. Herein, a targeted nanoplatform is reported based on sonodynamic therapy, the chitosan‐conjugated fucose loaded with indocyanine green (ICG@FCS). It penetrates the gastric mucosa and homes in on H. pylori through dual targeting mechanisms: molecular via fucose and physical via ultrasound. Upon ultrasound activation, it generates singlet oxygen, effectively attacking planktonic bacteria, disrupting biofilms, and facilitating the clearance of intracellular bacteria by promoting autophagy, including multidrug‐resistant strains. The ICG@FCS nanoplatform minimally affects the gut microbiota and aids in gastric mucosa repair. a holistic integrative H. pylori therapy strategy is proposed that targets eradication while preserving gastrointestinal health. This strategy emphasizes the importance of maintaining patient health while eradicating the pathogen. This advancement is set to refine the comprehensive antibacterial approach, offering a promising horizon in the ongoing battle against antibiotic resistance and more effective gastric cancer prevention strategies. |
| format | Article |
| id | doaj-art-18bff6b150394e19b5f8efbae00406cf |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-18bff6b150394e19b5f8efbae00406cf2025-01-13T15:29:43ZengWileyAdvanced Science2198-38442025-01-01122n/an/a10.1002/advs.202408583Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori TherapyXiaojing Yin0Yongkang Lai1Xinyuan Zhang2Tingling Zhang3Jing Tian4Yiqi Du5Zhaoshen Li6Jie Gao7Department of Gastroenterology Shanghai Institute of Pancreatic Diseases Changhai Hospital Shanghai 200433 ChinaDepartment of Gastroenterology Shanghai Institute of Pancreatic Diseases Changhai Hospital Shanghai 200433 ChinaSchool of Health Science and Engineering University of Shanghai for Science and Technology Shanghai 200093 ChinaChanghai Clinical Research Unit Changhai Hospital Naval Medical University Shanghai 200433 ChinaDepartment of Pharmacy Shanghai Changhai Hospital the First Affiliated Hospital of Navy Medical University Shanghai 200433 ChinaDepartment of Gastroenterology Shanghai Institute of Pancreatic Diseases Changhai Hospital Shanghai 200433 ChinaDepartment of Gastroenterology Shanghai Institute of Pancreatic Diseases Changhai Hospital Shanghai 200433 ChinaDepartment of Gastroenterology Shanghai Institute of Pancreatic Diseases Changhai Hospital Shanghai 200433 ChinaAbstract Helicobacter pylori (H. pylori) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along with the adverse effects caused by complicated medication protocols, has made the eradication of H. pylori a more formidable challenge, necessitating alternative therapeutics. Herein, a targeted nanoplatform is reported based on sonodynamic therapy, the chitosan‐conjugated fucose loaded with indocyanine green (ICG@FCS). It penetrates the gastric mucosa and homes in on H. pylori through dual targeting mechanisms: molecular via fucose and physical via ultrasound. Upon ultrasound activation, it generates singlet oxygen, effectively attacking planktonic bacteria, disrupting biofilms, and facilitating the clearance of intracellular bacteria by promoting autophagy, including multidrug‐resistant strains. The ICG@FCS nanoplatform minimally affects the gut microbiota and aids in gastric mucosa repair. a holistic integrative H. pylori therapy strategy is proposed that targets eradication while preserving gastrointestinal health. This strategy emphasizes the importance of maintaining patient health while eradicating the pathogen. This advancement is set to refine the comprehensive antibacterial approach, offering a promising horizon in the ongoing battle against antibiotic resistance and more effective gastric cancer prevention strategies.https://doi.org/10.1002/advs.202408583autophagybiofilmsHelicobacter pylori infectionholistic integrative medicinesonodynamic therapy |
| spellingShingle | Xiaojing Yin Yongkang Lai Xinyuan Zhang Tingling Zhang Jing Tian Yiqi Du Zhaoshen Li Jie Gao Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy Advanced Science autophagy biofilms Helicobacter pylori infection holistic integrative medicine sonodynamic therapy |
| title | Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy |
| title_full | Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy |
| title_fullStr | Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy |
| title_full_unstemmed | Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy |
| title_short | Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy |
| title_sort | targeted sonodynamic therapy platform for holistic integrative helicobacter pylori therapy |
| topic | autophagy biofilms Helicobacter pylori infection holistic integrative medicine sonodynamic therapy |
| url | https://doi.org/10.1002/advs.202408583 |
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