The determination of some biochemical parameters in rats treated with different doses of indomethacin
This study was carried out to investigate the changes occurring in the levels of serum aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), lactic dehydrogenase (LDH), creatin phosphokinase (CPK), sorbitol dehydrogenase (SDH), tot...
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=365 |
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| author | İzzet Karahan İbrahim Pirinçci Bülent Elitok Ahmet Ateşşahin |
| author_facet | İzzet Karahan İbrahim Pirinçci Bülent Elitok Ahmet Ateşşahin |
| author_sort | İzzet Karahan |
| collection | DOAJ |
| description | This study was carried out to investigate the changes occurring in the levels of serum aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), lactic dehydrogenase (LDH), creatin phosphokinase (CPK), sorbitol dehydrogenase (SDH), total bilirubin (TB), direct bilirubin (DB), total protein (TP), albumin (ALB), triglyceride (TG). glucose (GL) and osmolality (OSM) in rats given wilh three different doses of indomethacin. As materials, eighty-four rats were used. Indomethacin was given intramuscularly at the doses of 2.5, 5.0 and 7.5 mg/kg. The blood samples were collected at 0.5, 1, 2, 4. 8, 12 and 24th hours. These samples were analysed for the biochemical parameters. In conclusion, it was determined that indomethacin increased the levels of AST, ALT. GGT. ALP. LDH, CPK, SDH, TB, DB, GL and OSM in serum of rats experimentally given the different doses of indomethacin. In contrast, indomethacin was established to decrease the levels of TP, ALB and TG in serum of rats. |
| format | Article |
| id | doaj-art-18b93cb0d3aa442ca8b7ea1896a07ea4 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-18b93cb0d3aa442ca8b7ea1896a07ea42025-01-02T22:35:04ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19531623944365The determination of some biochemical parameters in rats treated with different doses of indomethacinİzzet Karahan0İbrahim Pirinçci1Bülent Elitok2Ahmet Ateşşahin3F.Ü. Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, ELAZIĞF.Ü. Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, ELAZIĞD.Ü. Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, DİYARBAKIRF.Ü. Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, ELAZIĞThis study was carried out to investigate the changes occurring in the levels of serum aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), lactic dehydrogenase (LDH), creatin phosphokinase (CPK), sorbitol dehydrogenase (SDH), total bilirubin (TB), direct bilirubin (DB), total protein (TP), albumin (ALB), triglyceride (TG). glucose (GL) and osmolality (OSM) in rats given wilh three different doses of indomethacin. As materials, eighty-four rats were used. Indomethacin was given intramuscularly at the doses of 2.5, 5.0 and 7.5 mg/kg. The blood samples were collected at 0.5, 1, 2, 4. 8, 12 and 24th hours. These samples were analysed for the biochemical parameters. In conclusion, it was determined that indomethacin increased the levels of AST, ALT. GGT. ALP. LDH, CPK, SDH, TB, DB, GL and OSM in serum of rats experimentally given the different doses of indomethacin. In contrast, indomethacin was established to decrease the levels of TP, ALB and TG in serum of rats.http://eurasianjvetsci.org/pdf.php3?id=365indomethacinratbiochemical parameters |
| spellingShingle | İzzet Karahan İbrahim Pirinçci Bülent Elitok Ahmet Ateşşahin The determination of some biochemical parameters in rats treated with different doses of indomethacin Eurasian Journal of Veterinary Sciences indomethacin rat biochemical parameters |
| title | The determination of some biochemical parameters in rats treated with different doses of indomethacin |
| title_full | The determination of some biochemical parameters in rats treated with different doses of indomethacin |
| title_fullStr | The determination of some biochemical parameters in rats treated with different doses of indomethacin |
| title_full_unstemmed | The determination of some biochemical parameters in rats treated with different doses of indomethacin |
| title_short | The determination of some biochemical parameters in rats treated with different doses of indomethacin |
| title_sort | determination of some biochemical parameters in rats treated with different doses of indomethacin |
| topic | indomethacin rat biochemical parameters |
| url | http://eurasianjvetsci.org/pdf.php3?id=365 |
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