Current challenges surrounding exosome treatments
Cardiovascular disease is the leading cause of death worldwide today and numerous studies are demonstrating that exosomes improve cardiac function after myocardial injury through various mechanisms. Exosome therapy has great potential as an effective precision medicine biologic by targeting the unde...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Extracellular Vesicle |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041723000021 |
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| _version_ | 1846159372383682560 |
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| author | Eileen Tzng Nathan Bayardo Phillip C. Yang |
| author_facet | Eileen Tzng Nathan Bayardo Phillip C. Yang |
| author_sort | Eileen Tzng |
| collection | DOAJ |
| description | Cardiovascular disease is the leading cause of death worldwide today and numerous studies are demonstrating that exosomes improve cardiac function after myocardial injury through various mechanisms. Exosome therapy has great potential as an effective precision medicine biologic by targeting the underlying disease process. However, this innovative approach may face some challenges, such as zeta potential, standardization of exosome collection, biopharmaceutical regulation, and more importantly, specific clinical application of exosome therapy. These issues will be addressed by broadly summarizing the biological plausibility; delivery, dosing, and pharmacokinetics; and reproducibility and manufacturing with a focus on microRNA as molecular cargo. |
| format | Article |
| id | doaj-art-18ade44e4cc64c13be11b12c60e63c3a |
| institution | Kabale University |
| issn | 2773-0417 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-18ade44e4cc64c13be11b12c60e63c3a2024-11-23T06:34:52ZengElsevierExtracellular Vesicle2773-04172023-12-012100023Current challenges surrounding exosome treatmentsEileen Tzng0Nathan Bayardo1Phillip C. Yang2Division of Cardiovascular Medicine and Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States of AmericaDivision of Cardiovascular Medicine and Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States of AmericaCorrespondence to: Division of Cardiovascular Medicine, Department of Medicine and Cardiovascular Institute, Stanford University School of Medicine, 240 Pasteur Dr, BMI, 3053 Stanford, CA 94305, United States of America.; Division of Cardiovascular Medicine and Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States of AmericaCardiovascular disease is the leading cause of death worldwide today and numerous studies are demonstrating that exosomes improve cardiac function after myocardial injury through various mechanisms. Exosome therapy has great potential as an effective precision medicine biologic by targeting the underlying disease process. However, this innovative approach may face some challenges, such as zeta potential, standardization of exosome collection, biopharmaceutical regulation, and more importantly, specific clinical application of exosome therapy. These issues will be addressed by broadly summarizing the biological plausibility; delivery, dosing, and pharmacokinetics; and reproducibility and manufacturing with a focus on microRNA as molecular cargo.http://www.sciencedirect.com/science/article/pii/S2773041723000021ExosomeTherapyCardiovascular disease |
| spellingShingle | Eileen Tzng Nathan Bayardo Phillip C. Yang Current challenges surrounding exosome treatments Extracellular Vesicle Exosome Therapy Cardiovascular disease |
| title | Current challenges surrounding exosome treatments |
| title_full | Current challenges surrounding exosome treatments |
| title_fullStr | Current challenges surrounding exosome treatments |
| title_full_unstemmed | Current challenges surrounding exosome treatments |
| title_short | Current challenges surrounding exosome treatments |
| title_sort | current challenges surrounding exosome treatments |
| topic | Exosome Therapy Cardiovascular disease |
| url | http://www.sciencedirect.com/science/article/pii/S2773041723000021 |
| work_keys_str_mv | AT eileentzng currentchallengessurroundingexosometreatments AT nathanbayardo currentchallengessurroundingexosometreatments AT phillipcyang currentchallengessurroundingexosometreatments |