High‐dose intranasal insulin in an adaptive dose‐escalation study in healthy human participants

Abstract Intranasal insulin is a putative neuroprotective therapy after cardiac arrest, but safety in humans at doses extrapolated from animal models is unknown. This phase I, open‐label adaptive dose‐escalation study explores the maximum tolerated dose of intranasal insulin in healthy human partici...

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Bibliographic Details
Main Authors: Florian Schmitzberger, Jennifer Fowler, Cindy H. Hsu, Manjunath P. Pai, Robert W. Neumar, William J. Meurer, Robert Silbergleit
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.70071
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