Lentivirus-based production of human chimeric antigen receptor macrophages from peripheral blood

Lentivirus-based production of human chimeric antigen receptor macrophages from peripheral blood

Abstract Although chimeric antigen receptor (CAR) T cell therapy has shown remarkable efficacy against leukemic cells, it still has critical limitations. CAR macrophage has been regarded as a potential alternative to CAR T cells. However, due to the difficulties in gene transduction into macrophages...

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Bibliographic Details
Main Authors: Ji U Choi, Yeongrin Kim, Da Yeon Lee, Jin Song Park, Moonjung Jeun, Heung Kyoung Lee, Chi Hoon Park
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biomarker Research
Subjects:
CAR macrophages
Lentivirus
Human PBMC
Primary human macrophages
Online Access:https://doi.org/10.1186/s40364-024-00703-9
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