Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project
Purpose The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother–child pregnancy and birth cohort originally initiated in the mid-1990s to explore: (1) whether enhanced mobilisation of lead from maternal bone stores during pregnancy poses a risk to fetal and subsequ...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2019-08-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/8/e030427.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850146585592201216 |
|---|---|
| author | Lu Tang Manish Arora Wei Perng Marcela Tamayo-Ortiz Brisa N Sánchez Alejandra Cantoral John D Meeker Dana C Dolinoy Elizabeth F Roberts Esperanza Angeles Martinez-Mier Hector Lamadrid-Figueroa Peter X K Song Adrienne S Ettinger Robert Wright Lourdes Schnaas Deborah J Watkins Jaclyn M Goodrich Robin C Garcia Maritsa Solano-Gonzalez Luis F Bautista-Arredondo Adriana Mercado-Garcia Howard Hu Mauricio Hernandez-Avila Martha Maria Tellez-Rojo Karen E Peterson |
| author_facet | Lu Tang Manish Arora Wei Perng Marcela Tamayo-Ortiz Brisa N Sánchez Alejandra Cantoral John D Meeker Dana C Dolinoy Elizabeth F Roberts Esperanza Angeles Martinez-Mier Hector Lamadrid-Figueroa Peter X K Song Adrienne S Ettinger Robert Wright Lourdes Schnaas Deborah J Watkins Jaclyn M Goodrich Robin C Garcia Maritsa Solano-Gonzalez Luis F Bautista-Arredondo Adriana Mercado-Garcia Howard Hu Mauricio Hernandez-Avila Martha Maria Tellez-Rojo Karen E Peterson |
| author_sort | Lu Tang |
| collection | DOAJ |
| description | Purpose The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother–child pregnancy and birth cohort originally initiated in the mid-1990s to explore: (1) whether enhanced mobilisation of lead from maternal bone stores during pregnancy poses a risk to fetal and subsequent offspring neurodevelopment; and (2) whether maternal calcium supplementation during pregnancy and lactation can suppress bone lead mobilisation and mitigate the adverse effects of lead exposure on offspring health and development. Through utilisation of carefully archived biospecimens to measure other prenatal exposures, banking of DNA and rigorous measurement of a diverse array of outcomes, ELEMENT has since evolved into a major resource for research on early life exposures and developmental outcomes.Participants n=1643 mother–child pairs sequentially recruited (between 1994 and 2003) during pregnancy or at delivery from maternity hospitals in Mexico City, Mexico.Findings to date Maternal bone (eg, patella, tibia) is an endogenous source for fetal lead exposure due to mobilisation of stored lead into circulation during pregnancy and lactation, leading to increased risk of miscarriage, low birth weight and smaller head circumference, and transfer of lead into breastmilk. Daily supplementation with 1200 mg of elemental calcium during pregnancy and lactation reduces lead resorption from maternal bone and thereby, levels of circulating lead. Beyond perinatal outcomes, early life exposure to lead is associated with neurocognitive deficits, behavioural disorders, higher blood pressure and lower weight in offspring during childhood. Some of these relationships were modified by dietary factors; genetic polymorphisms specific for iron, folate and lipid metabolism; and timing of exposure. Research has also expanded to include findings published on other toxicants such as those associated with personal care products and plastics (eg, phthalates, bisphenol A), other metals (eg, mercury, manganese, cadmium), pesticides (organophosphates) and fluoride; other biomarkers (eg, toxicant levels in plasma, hair and teeth); other outcomes (eg, sexual maturation, metabolic syndrome, dental caries); and identification of novel mechanisms via epigenetic and metabolomics profiling.Future plans As the ELEMENT mothers and children age, we plan to (1) continue studying the long-term consequences of toxicant exposure during the perinatal period on adolescent and young adult outcomes as well as outcomes related to the original ELEMENT mothers, such as their metabolic and bone health during perimenopause; and (2) follow the third generation of participants (children of the children) to study intergenerational effects of in utero exposures.Trial registration number NCT00558623. |
| format | Article |
| id | doaj-art-186db3cb5f0e45eb90f2444161bb7485 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-186db3cb5f0e45eb90f2444161bb74852025-08-20T02:27:49ZengBMJ Publishing GroupBMJ Open2044-60552019-08-019810.1136/bmjopen-2019-030427Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) ProjectLu Tang0Manish Arora1Wei Perng2Marcela Tamayo-Ortiz3Brisa N Sánchez4Alejandra Cantoral5John D Meeker6Dana C Dolinoy7Elizabeth F Roberts8Esperanza Angeles Martinez-Mier9Hector Lamadrid-Figueroa10Peter X K Song11Adrienne S Ettinger12Robert Wright13Lourdes Schnaas14Deborah J Watkins15Jaclyn M Goodrich16Robin C Garcia17Maritsa Solano-Gonzalez18Luis F Bautista-Arredondo19Adriana Mercado-Garcia20Howard Hu21Mauricio Hernandez-Avila22Martha Maria Tellez-Rojo23Karen E Peterson24Anesthesia and Pain Medical Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, ChinaDepartment of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai Hospital, New York, New York, USADepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver Anschutz Medical Center, Aurora, Colorado, USACenter for Research in Nutrition and Health, National Institute of Public Health, Cuernavaca, MexicoDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USACenter for Research in Nutrition and Health, National Institute of Public Health, Cuernavaca, MexicoDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USADepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USADepartment of Anthropology, University of Michigan, Ann Arbor, Michigan, USADepartment of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USACenter for Population Health Research, National Institute of Public Health, Cuernavaca, MexicoDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USADepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA1King’s College LondonDivision of Research in Community Interventions, Instituto Nacional de Perinatologia, Mexico City, MexicoDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USADepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USADepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USACenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, MexicoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, MexicoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico6Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USADirección de Prestaciones Económicas y Sociales, Mexican Institute of Social Security, Mexico City, MexicoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, MexicoDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USAPurpose The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother–child pregnancy and birth cohort originally initiated in the mid-1990s to explore: (1) whether enhanced mobilisation of lead from maternal bone stores during pregnancy poses a risk to fetal and subsequent offspring neurodevelopment; and (2) whether maternal calcium supplementation during pregnancy and lactation can suppress bone lead mobilisation and mitigate the adverse effects of lead exposure on offspring health and development. Through utilisation of carefully archived biospecimens to measure other prenatal exposures, banking of DNA and rigorous measurement of a diverse array of outcomes, ELEMENT has since evolved into a major resource for research on early life exposures and developmental outcomes.Participants n=1643 mother–child pairs sequentially recruited (between 1994 and 2003) during pregnancy or at delivery from maternity hospitals in Mexico City, Mexico.Findings to date Maternal bone (eg, patella, tibia) is an endogenous source for fetal lead exposure due to mobilisation of stored lead into circulation during pregnancy and lactation, leading to increased risk of miscarriage, low birth weight and smaller head circumference, and transfer of lead into breastmilk. Daily supplementation with 1200 mg of elemental calcium during pregnancy and lactation reduces lead resorption from maternal bone and thereby, levels of circulating lead. Beyond perinatal outcomes, early life exposure to lead is associated with neurocognitive deficits, behavioural disorders, higher blood pressure and lower weight in offspring during childhood. Some of these relationships were modified by dietary factors; genetic polymorphisms specific for iron, folate and lipid metabolism; and timing of exposure. Research has also expanded to include findings published on other toxicants such as those associated with personal care products and plastics (eg, phthalates, bisphenol A), other metals (eg, mercury, manganese, cadmium), pesticides (organophosphates) and fluoride; other biomarkers (eg, toxicant levels in plasma, hair and teeth); other outcomes (eg, sexual maturation, metabolic syndrome, dental caries); and identification of novel mechanisms via epigenetic and metabolomics profiling.Future plans As the ELEMENT mothers and children age, we plan to (1) continue studying the long-term consequences of toxicant exposure during the perinatal period on adolescent and young adult outcomes as well as outcomes related to the original ELEMENT mothers, such as their metabolic and bone health during perimenopause; and (2) follow the third generation of participants (children of the children) to study intergenerational effects of in utero exposures.Trial registration number NCT00558623.https://bmjopen.bmj.com/content/9/8/e030427.full |
| spellingShingle | Lu Tang Manish Arora Wei Perng Marcela Tamayo-Ortiz Brisa N Sánchez Alejandra Cantoral John D Meeker Dana C Dolinoy Elizabeth F Roberts Esperanza Angeles Martinez-Mier Hector Lamadrid-Figueroa Peter X K Song Adrienne S Ettinger Robert Wright Lourdes Schnaas Deborah J Watkins Jaclyn M Goodrich Robin C Garcia Maritsa Solano-Gonzalez Luis F Bautista-Arredondo Adriana Mercado-Garcia Howard Hu Mauricio Hernandez-Avila Martha Maria Tellez-Rojo Karen E Peterson Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project BMJ Open |
| title | Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project |
| title_full | Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project |
| title_fullStr | Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project |
| title_full_unstemmed | Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project |
| title_short | Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project |
| title_sort | early life exposure in mexico to environmental toxicants element project |
| url | https://bmjopen.bmj.com/content/9/8/e030427.full |
| work_keys_str_mv | AT lutang earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT manisharora earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT weiperng earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT marcelatamayoortiz earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT brisansanchez earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT alejandracantoral earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT johndmeeker earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT danacdolinoy earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT elizabethfroberts earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT esperanzaangelesmartinezmier earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT hectorlamadridfigueroa earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT peterxksong earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT adriennesettinger earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT robertwright earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT lourdesschnaas earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT deborahjwatkins earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT jaclynmgoodrich earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT robincgarcia earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT maritsasolanogonzalez earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT luisfbautistaarredondo earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT adrianamercadogarcia earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT howardhu earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT mauriciohernandezavila earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT marthamariatellezrojo earlylifeexposureinmexicotoenvironmentaltoxicantselementproject AT karenepeterson earlylifeexposureinmexicotoenvironmentaltoxicantselementproject |