Enhancing Antibacterial Efficacy: Combining Novel Bacterial Topoisomerase Inhibitors with Efflux Pump Inhibitors and Other Agents Against Gram-Negative Bacteria

Enhancing Antibacterial Efficacy: Combining Novel Bacterial Topoisomerase Inhibitors with Efflux Pump Inhibitors and Other Agents Against Gram-Negative Bacteria

Background: The novel bacterial topoisomerase inhibitors (NBTIs) developed in our laboratory show potent on-target enzyme inhibition but suffer from low activity against Gram-negative bacteria. Methods: With the aim of improving the antibacterial activity of our compounds against Gram-negative bacte...

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Bibliographic Details
Main Authors: Maša Zorman, Maja Kokot, Irena Zdovc, Lidija Senerovic, Mina Mandic, Nace Zidar, Andrej Emanuel Cotman, Martina Durcik, Lucija Peterlin Mašič, Nikola Minovski, Marko Anderluh, Martina Hrast Rambaher
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Antibiotics
Subjects:
topoisomerase inhibitors
NBTIs
efflux pump inhibitors
ESKAPE pathogens
antimicrobial resistance
bacterial biofilms
Online Access:https://www.mdpi.com/2079-6382/13/11/1081
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