The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis

The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis

Abstract Background Polygenic risk scores for educational attainment (PRSEA), cognitive reserve (CR), and clinical symptoms are associated with functioning in first-episode psychosis (FEP). Nevertheless, the mechanisms underlying their complex interaction are yet to be explored. This study assesse...

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Main Authors: Derek Clougher, Àlex G. Segura, Maria F. Forte, Gisela Mezquida, Manuel J. Cuesta, Eduard Vieta, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Covadonga M. Díaz-Caneja, Alexandra Roldán, Giovanna Fico, Elena de la Serna, Daniel Bergé, Patricia Gassó, Natalia Rodriguez, Norma Verdolini, Alfonso Tortorella, Giulia Menculini, Marta Ribasés, Miguel Bernardo, Sergi Mas
Format: Article
Language:English
Published: Cambridge University Press 2025-01-01
Series:European Psychiatry
Subjects:
cognitive reserve
first-episode psychosis
functioning
negative symptoms
polygenic risk score
Online Access:https://www.cambridge.org/core/product/identifier/S092493382302480X/type/journal_article
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