FAM83A-AS1 predicts severe development of non-small cell lung cancer and adverse postoperative prognosis of thoracotomy
Abstract Background Thoracotomy is a common treatment for non-small cell lung cancer (NSCLC). However, the significant trauma from this procedure can limit patients’ postoperative prognosis. Therefore, it’s crucial to find an easily detected indicator that can predict the prognosis of NSCLC patients...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-024-03235-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544263194640384 |
|---|---|
| author | Feng Tang Yuemian Liang Licai Zhang Liquan Qiu Chengcheng Xu |
| author_facet | Feng Tang Yuemian Liang Licai Zhang Liquan Qiu Chengcheng Xu |
| author_sort | Feng Tang |
| collection | DOAJ |
| description | Abstract Background Thoracotomy is a common treatment for non-small cell lung cancer (NSCLC). However, the significant trauma from this procedure can limit patients’ postoperative prognosis. Therefore, it’s crucial to find an easily detected indicator that can predict the prognosis of NSCLC patients undergoing thoracotomy. FAM83A-AS1 was hypothesized as a predictor for the therapeutic effectiveness of thoracotomy. We evaluated its correlation with patient outcomes and its significance in predicting postoperative prognosis, with the aim of providing a reference to improve postoperative prognosis of thoracotomy. Materials and methods The study enrolled patients with NSCLC who underwent thoracotomy, and tissue samples were collected during surgery. Blood samples were collected preoperatively and three days postoperatively. PCR was used to analyze plasma FAM83A-AS1 levels. The significance of these levels in the patients’ postoperative prognosis was evaluated via logistic regression and ROC analyses, with a follow-up period of six months. Results FAM83A-AS1 was significantly upregulated in NSCLC and correlated with severe progression in patients. Thoracotomy suppressed FAM83A-AS1 expression and reduced CA50, CEA, and CYFRA21-1 levels. Postoperative plasma levels of FAM83A-AS1 positively correlated with CA50, CEA, and CYFRA21-1. Patients with worse prognoses had higher plasma FAM83A-AS1 levels. FAM83A-AS1 was identified as a risk factor for poor postoperative outcomes in NSCLC patients undergoing thoracotomy and could be used to identify patients at risk of worse prognosis. Conclusion An increase in FAM83A-AS1 in NSCL indicates severe disease development and can serve as a biomarker associated with thoracotomy, predicting a poor prognosis. It provides a potential indicator for patient outcomes. |
| format | Article |
| id | doaj-art-17ed2127982448c2abb0fbb11768095b |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-17ed2127982448c2abb0fbb11768095b2025-01-12T12:39:07ZengBMCJournal of Cardiothoracic Surgery1749-80902025-01-012011710.1186/s13019-024-03235-3FAM83A-AS1 predicts severe development of non-small cell lung cancer and adverse postoperative prognosis of thoracotomyFeng Tang0Yuemian Liang1Licai Zhang2Liquan Qiu3Chengcheng Xu4Department of Respiratory and Critical Care, Shanghai Pulmonary HospitalDepartment of Pathology, Affiliated Hospital of Hebei UniversityDepartment of Anesthesiology, Zigong Fourth People’s HospitalDepartment of Anesthesiology, Zigong Fourth People’s HospitalDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow UniversityAbstract Background Thoracotomy is a common treatment for non-small cell lung cancer (NSCLC). However, the significant trauma from this procedure can limit patients’ postoperative prognosis. Therefore, it’s crucial to find an easily detected indicator that can predict the prognosis of NSCLC patients undergoing thoracotomy. FAM83A-AS1 was hypothesized as a predictor for the therapeutic effectiveness of thoracotomy. We evaluated its correlation with patient outcomes and its significance in predicting postoperative prognosis, with the aim of providing a reference to improve postoperative prognosis of thoracotomy. Materials and methods The study enrolled patients with NSCLC who underwent thoracotomy, and tissue samples were collected during surgery. Blood samples were collected preoperatively and three days postoperatively. PCR was used to analyze plasma FAM83A-AS1 levels. The significance of these levels in the patients’ postoperative prognosis was evaluated via logistic regression and ROC analyses, with a follow-up period of six months. Results FAM83A-AS1 was significantly upregulated in NSCLC and correlated with severe progression in patients. Thoracotomy suppressed FAM83A-AS1 expression and reduced CA50, CEA, and CYFRA21-1 levels. Postoperative plasma levels of FAM83A-AS1 positively correlated with CA50, CEA, and CYFRA21-1. Patients with worse prognoses had higher plasma FAM83A-AS1 levels. FAM83A-AS1 was identified as a risk factor for poor postoperative outcomes in NSCLC patients undergoing thoracotomy and could be used to identify patients at risk of worse prognosis. Conclusion An increase in FAM83A-AS1 in NSCL indicates severe disease development and can serve as a biomarker associated with thoracotomy, predicting a poor prognosis. It provides a potential indicator for patient outcomes.https://doi.org/10.1186/s13019-024-03235-3BiomarkerTherapeutic targetThoracotomy surgeryPrognosisTumor marker |
| spellingShingle | Feng Tang Yuemian Liang Licai Zhang Liquan Qiu Chengcheng Xu FAM83A-AS1 predicts severe development of non-small cell lung cancer and adverse postoperative prognosis of thoracotomy Journal of Cardiothoracic Surgery Biomarker Therapeutic target Thoracotomy surgery Prognosis Tumor marker |
| title | FAM83A-AS1 predicts severe development of non-small cell lung cancer and adverse postoperative prognosis of thoracotomy |
| title_full | FAM83A-AS1 predicts severe development of non-small cell lung cancer and adverse postoperative prognosis of thoracotomy |
| title_fullStr | FAM83A-AS1 predicts severe development of non-small cell lung cancer and adverse postoperative prognosis of thoracotomy |
| title_full_unstemmed | FAM83A-AS1 predicts severe development of non-small cell lung cancer and adverse postoperative prognosis of thoracotomy |
| title_short | FAM83A-AS1 predicts severe development of non-small cell lung cancer and adverse postoperative prognosis of thoracotomy |
| title_sort | fam83a as1 predicts severe development of non small cell lung cancer and adverse postoperative prognosis of thoracotomy |
| topic | Biomarker Therapeutic target Thoracotomy surgery Prognosis Tumor marker |
| url | https://doi.org/10.1186/s13019-024-03235-3 |
| work_keys_str_mv | AT fengtang fam83aas1predictsseveredevelopmentofnonsmallcelllungcancerandadversepostoperativeprognosisofthoracotomy AT yuemianliang fam83aas1predictsseveredevelopmentofnonsmallcelllungcancerandadversepostoperativeprognosisofthoracotomy AT licaizhang fam83aas1predictsseveredevelopmentofnonsmallcelllungcancerandadversepostoperativeprognosisofthoracotomy AT liquanqiu fam83aas1predictsseveredevelopmentofnonsmallcelllungcancerandadversepostoperativeprognosisofthoracotomy AT chengchengxu fam83aas1predictsseveredevelopmentofnonsmallcelllungcancerandadversepostoperativeprognosisofthoracotomy |