Neural Circuit Remodeling: Mechanistic Insights from Invertebrates
As nervous systems mature, neural circuit connections are reorganized to optimize the performance of specific functions in adults. This reorganization of connections is achieved through a remarkably conserved phase of developmental circuit remodeling that engages neuron-intrinsic and neuron-extrinsi...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Journal of Developmental Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2221-3759/12/4/27 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846104193442512896 |
|---|---|
| author | Samuel Liu Kellianne D. Alexander Michael M. Francis |
| author_facet | Samuel Liu Kellianne D. Alexander Michael M. Francis |
| author_sort | Samuel Liu |
| collection | DOAJ |
| description | As nervous systems mature, neural circuit connections are reorganized to optimize the performance of specific functions in adults. This reorganization of connections is achieved through a remarkably conserved phase of developmental circuit remodeling that engages neuron-intrinsic and neuron-extrinsic molecular mechanisms to establish mature circuitry. Abnormalities in circuit remodeling and maturation are broadly linked with a variety of neurodevelopmental disorders, including autism spectrum disorders and schizophrenia. Here, we aim to provide an overview of recent advances in our understanding of the molecular processes that govern neural circuit remodeling and maturation. In particular, we focus on intriguing mechanistic insights gained from invertebrate systems, such as the nematode <i>Caenorhabditis elegans</i> and the fruit fly <i>Drosophila melanogaster</i>. We discuss how transcriptional control mechanisms, synaptic activity, and glial engulfment shape specific aspects of circuit remodeling in worms and flies. Finally, we highlight mechanistic parallels across invertebrate and mammalian systems, and prospects for further advances in each. |
| format | Article |
| id | doaj-art-17cc9532ad4440cead80bb05ecb8fc3d |
| institution | Kabale University |
| issn | 2221-3759 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj-art-17cc9532ad4440cead80bb05ecb8fc3d2024-12-27T14:31:57ZengMDPI AGJournal of Developmental Biology2221-37592024-10-011242710.3390/jdb12040027Neural Circuit Remodeling: Mechanistic Insights from InvertebratesSamuel Liu0Kellianne D. Alexander1Michael M. Francis2Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USADepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USADepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USAAs nervous systems mature, neural circuit connections are reorganized to optimize the performance of specific functions in adults. This reorganization of connections is achieved through a remarkably conserved phase of developmental circuit remodeling that engages neuron-intrinsic and neuron-extrinsic molecular mechanisms to establish mature circuitry. Abnormalities in circuit remodeling and maturation are broadly linked with a variety of neurodevelopmental disorders, including autism spectrum disorders and schizophrenia. Here, we aim to provide an overview of recent advances in our understanding of the molecular processes that govern neural circuit remodeling and maturation. In particular, we focus on intriguing mechanistic insights gained from invertebrate systems, such as the nematode <i>Caenorhabditis elegans</i> and the fruit fly <i>Drosophila melanogaster</i>. We discuss how transcriptional control mechanisms, synaptic activity, and glial engulfment shape specific aspects of circuit remodeling in worms and flies. Finally, we highlight mechanistic parallels across invertebrate and mammalian systems, and prospects for further advances in each.https://www.mdpi.com/2221-3759/12/4/27<i>C. elegans</i><i>Drosophila</i>neural circuitsremodelingsynapse eliminationtranscriptional regulation |
| spellingShingle | Samuel Liu Kellianne D. Alexander Michael M. Francis Neural Circuit Remodeling: Mechanistic Insights from Invertebrates Journal of Developmental Biology <i>C. elegans</i> <i>Drosophila</i> neural circuits remodeling synapse elimination transcriptional regulation |
| title | Neural Circuit Remodeling: Mechanistic Insights from Invertebrates |
| title_full | Neural Circuit Remodeling: Mechanistic Insights from Invertebrates |
| title_fullStr | Neural Circuit Remodeling: Mechanistic Insights from Invertebrates |
| title_full_unstemmed | Neural Circuit Remodeling: Mechanistic Insights from Invertebrates |
| title_short | Neural Circuit Remodeling: Mechanistic Insights from Invertebrates |
| title_sort | neural circuit remodeling mechanistic insights from invertebrates |
| topic | <i>C. elegans</i> <i>Drosophila</i> neural circuits remodeling synapse elimination transcriptional regulation |
| url | https://www.mdpi.com/2221-3759/12/4/27 |
| work_keys_str_mv | AT samuelliu neuralcircuitremodelingmechanisticinsightsfrominvertebrates AT kelliannedalexander neuralcircuitremodelingmechanisticinsightsfrominvertebrates AT michaelmfrancis neuralcircuitremodelingmechanisticinsightsfrominvertebrates |