Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline, ultimately culminating in dementia. This study aims to evaluate cerebrovascular reactivity (CVR) and functional connectivity (FC) in patients with AD and mild cogni...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-82769-x |
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| author | Xue Tang Luoyu Wang Qi Feng Hanjun Hu Yidi Zhu Zhengluan Liao Zhongxiang Ding Xiufang Xu |
| author_facet | Xue Tang Luoyu Wang Qi Feng Hanjun Hu Yidi Zhu Zhengluan Liao Zhongxiang Ding Xiufang Xu |
| author_sort | Xue Tang |
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| description | Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline, ultimately culminating in dementia. This study aims to evaluate cerebrovascular reactivity (CVR) and functional connectivity (FC) in patients with AD and mild cognitive impairment (MCI) using resting-state functional magnetic resonance imaging (rs-fMRI), bypassing the requirement for hypercapnia. The study cohort comprised 53 AD patients, 38 MCI patients, and 39 normal control (NC) subjects. CVR is derived by extracting signals within specific frequency bands of rs-fMRI. This study compares the differences in CVR and FC among the three groups, using the brain regions with CVR differences as region of interest (ROI) for FC analysis. The correlation between CVR and FC and cognitive scale score was discussed. Compared with NC subjects, AD patients exhibited a decrease in CVR in the PCUN.L, whereas MCI patients showed an increase in CVR in the PCUN.R. With PCUN.L as ROI, FC in PCUN.R decreased in AD patients, and FC in SFGmed.R and other brain regions increased in MCI patients compared with NC subjects. The results of the correlation analysis indicate that CVR in all patients, as well as FC with the PCUN.L as the ROI to the PCUN.R and SFGmed.R, show positive correlations with MMSE and MoCA scores. These results suggest that there are significant differences between CVR and FC with CVR differential brain regions as ROI among the AD, MCI, and NC groups, which may help to explain the hemodynamic mechanism. CVR obtained with rs-fMRI may be a potential biomarker for assessing cognitive impairment. |
| format | Article |
| id | doaj-art-17c3387ec47e44ae8f80c7d9bf244947 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-17c3387ec47e44ae8f80c7d9bf2449472025-01-05T12:14:57ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-82769-xResting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patientsXue Tang0Luoyu Wang1Qi Feng2Hanjun Hu3Yidi Zhu4Zhengluan Liao5Zhongxiang Ding6Xiufang Xu7School of Medical Imaging, Hangzhou Medical CollegeSchool of Biomedical Engineering, Shanghai Tech UniversityDepartment of Radiology, Hangzhou First People’s HospitalDepartment of Radiology, Hangzhou First People’s HospitalSchool of Medical Imaging, Hangzhou Medical CollegeDepartment of Psychiatry, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeDepartment of Radiology, Hangzhou First People’s HospitalSchool of Medical Imaging, Hangzhou Medical CollegeAbstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline, ultimately culminating in dementia. This study aims to evaluate cerebrovascular reactivity (CVR) and functional connectivity (FC) in patients with AD and mild cognitive impairment (MCI) using resting-state functional magnetic resonance imaging (rs-fMRI), bypassing the requirement for hypercapnia. The study cohort comprised 53 AD patients, 38 MCI patients, and 39 normal control (NC) subjects. CVR is derived by extracting signals within specific frequency bands of rs-fMRI. This study compares the differences in CVR and FC among the three groups, using the brain regions with CVR differences as region of interest (ROI) for FC analysis. The correlation between CVR and FC and cognitive scale score was discussed. Compared with NC subjects, AD patients exhibited a decrease in CVR in the PCUN.L, whereas MCI patients showed an increase in CVR in the PCUN.R. With PCUN.L as ROI, FC in PCUN.R decreased in AD patients, and FC in SFGmed.R and other brain regions increased in MCI patients compared with NC subjects. The results of the correlation analysis indicate that CVR in all patients, as well as FC with the PCUN.L as the ROI to the PCUN.R and SFGmed.R, show positive correlations with MMSE and MoCA scores. These results suggest that there are significant differences between CVR and FC with CVR differential brain regions as ROI among the AD, MCI, and NC groups, which may help to explain the hemodynamic mechanism. CVR obtained with rs-fMRI may be a potential biomarker for assessing cognitive impairment.https://doi.org/10.1038/s41598-024-82769-xAlzheimer’s diseasemild cognitive impairmentresting-state functional magnetic resonance imagingcerebrovascular reactivity |
| spellingShingle | Xue Tang Luoyu Wang Qi Feng Hanjun Hu Yidi Zhu Zhengluan Liao Zhongxiang Ding Xiufang Xu Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients Scientific Reports Alzheimer’s disease mild cognitive impairment resting-state functional magnetic resonance imaging cerebrovascular reactivity |
| title | Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients |
| title_full | Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients |
| title_fullStr | Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients |
| title_full_unstemmed | Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients |
| title_short | Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients |
| title_sort | resting state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of alzheimer s disease and mild cognitive impairment patients |
| topic | Alzheimer’s disease mild cognitive impairment resting-state functional magnetic resonance imaging cerebrovascular reactivity |
| url | https://doi.org/10.1038/s41598-024-82769-x |
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