Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells

Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells

Summary: PD-1 blockade enhances anti-tumoral CD8+ T cell responses via type 1 conventional dendritic cells (cDC1s), but how cDC1s change the properties of intratumoral CD8+ T cells remains to be determined. Here, we identified two populations of intratumoral CD8+ T cells distinguished by their expre...

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Bibliographic Details
Main Authors: Dongmin Chun, Jiyeon Park, Seulgi Lee, Hyo Jae Kim, Jong-Eun Park, Suk-Jo Kang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724013743
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