Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
Abstract Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable char...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Bioengineering & Translational Medicine |
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| Online Access: | https://doi.org/10.1002/btm2.10325 |
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| author | Milad Ashrafizadeh Kiavash Hushmandi Sepideh Mirzaei Saied Bokaie Ashkan Bigham Pooyan Makvandi Navid Rabiee Vijay Kumar Thakur Alan Prem Kumar Esmaeel Sharifi Rajender S. Varma Amir Reza Aref Marcin Wojnilowicz Ali Zarrabi Hassan Karimi‐Maleh Nicolas H. Voelcker Ebrahim Mostafavi Gorka Orive |
| author_facet | Milad Ashrafizadeh Kiavash Hushmandi Sepideh Mirzaei Saied Bokaie Ashkan Bigham Pooyan Makvandi Navid Rabiee Vijay Kumar Thakur Alan Prem Kumar Esmaeel Sharifi Rajender S. Varma Amir Reza Aref Marcin Wojnilowicz Ali Zarrabi Hassan Karimi‐Maleh Nicolas H. Voelcker Ebrahim Mostafavi Gorka Orive |
| author_sort | Milad Ashrafizadeh |
| collection | DOAJ |
| description | Abstract Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS‐based nanoparticles (CS‐NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS‐NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P‐glycoprotein (P‐gp) to reverse drug resistance. These nanoarchitectures can provide co‐delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co‐loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid‐, carbon‐, polymeric‐ and metal‐based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS‐NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS‐NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH‐sensitive release of DOX can occur. Furthermore, redox‐ and light‐responsive CS‐NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS‐NPs, we expect to soon see significant progress towards clinical translation. |
| format | Article |
| id | doaj-art-17991ffd95d3418c86d98d25e10ef291 |
| institution | Kabale University |
| issn | 2380-6761 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj-art-17991ffd95d3418c86d98d25e10ef2912024-11-21T05:16:02ZengWileyBioengineering & Translational Medicine2380-67612023-01-0181n/an/a10.1002/btm2.10325Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapyMilad Ashrafizadeh0Kiavash Hushmandi1Sepideh Mirzaei2Saied Bokaie3Ashkan Bigham4Pooyan Makvandi5Navid Rabiee6Vijay Kumar Thakur7Alan Prem Kumar8Esmaeel Sharifi9Rajender S. Varma10Amir Reza Aref11Marcin Wojnilowicz12Ali Zarrabi13Hassan Karimi‐Maleh14Nicolas H. Voelcker15Ebrahim Mostafavi16Gorka Orive17Faculty of Engineering and Natural Sciences Sabanci University, Üniversite Caddesi Tuzla, Istanbul TurkeyDepartment of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine University of Tehran Tehran IranDepartment of Biology, Faculty of Science Islamic Azad University, Science and Research Branch Tehran IranDepartment of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine University of Tehran Tehran IranInstitute of Polymers, Composites and Biomaterials ‐ National Research Council (IPCB‐CNR) Naples ItalyIstituto Italiano di Tecnologia, Center for Materials Interfaces Pontedera, Pisa ItalySchool of Engineering, Macquarie University Sydney New South Wales AustraliaSchool of Engineering University of Petroleum & Energy Studies (UPES) Dehradun Uttarakhand IndiaNUS Centre for Cancer Research (N2CR) Yong Loo Lin School of Medicine, National University of Singapore Singapore SingaporeDepartment of Tissue Engineering and Biomaterials School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences Hamadan IranRegional Center of Advanced Technologies and Materials Czech Advanced Technology and Research Institute, Palacky University Olomouc Czech RepublicXsphera Biosciences Inc. Boston Massachusetts USACommonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing Clayton Victoria AustraliaDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences Istinye University Istanbul TurkeySchool of Resources and Environment, University of Electronic Science and Technology of China Chengdu PR ChinaCommonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing Clayton Victoria AustraliaStanford Cardiovascular Institute, Stanford University School of Medicine Stanford California USANanoBioCel Research Group, School of Pharmacy University of the Basque Country (UPV/EHU) Vitoria‐Gasteiz SpainAbstract Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS‐based nanoparticles (CS‐NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS‐NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P‐glycoprotein (P‐gp) to reverse drug resistance. These nanoarchitectures can provide co‐delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co‐loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid‐, carbon‐, polymeric‐ and metal‐based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS‐NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS‐NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH‐sensitive release of DOX can occur. Furthermore, redox‐ and light‐responsive CS‐NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS‐NPs, we expect to soon see significant progress towards clinical translation.https://doi.org/10.1002/btm2.10325chitosandrug resistancegene therapystimuli‐responsive nanocarrierssynergistic therapy |
| spellingShingle | Milad Ashrafizadeh Kiavash Hushmandi Sepideh Mirzaei Saied Bokaie Ashkan Bigham Pooyan Makvandi Navid Rabiee Vijay Kumar Thakur Alan Prem Kumar Esmaeel Sharifi Rajender S. Varma Amir Reza Aref Marcin Wojnilowicz Ali Zarrabi Hassan Karimi‐Maleh Nicolas H. Voelcker Ebrahim Mostafavi Gorka Orive Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy Bioengineering & Translational Medicine chitosan drug resistance gene therapy stimuli‐responsive nanocarriers synergistic therapy |
| title | Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy |
| title_full | Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy |
| title_fullStr | Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy |
| title_full_unstemmed | Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy |
| title_short | Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy |
| title_sort | chitosan based nanoscale systems for doxorubicin delivery exploring biomedical application in cancer therapy |
| topic | chitosan drug resistance gene therapy stimuli‐responsive nanocarriers synergistic therapy |
| url | https://doi.org/10.1002/btm2.10325 |
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