Hyaluronan in COVID-19: a matrix for understanding lung disease
ABSTRACT The polysaccharide hyaluronan (HA) is an important component of lung extracellular matrix that increases following infection with influenza or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hellman et al. (U. Hellman, E. Rosendal, J. Lehrstrand, J. Henriksson, et al., mBio 15...
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| Language: | English |
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American Society for Microbiology
2024-12-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.02609-24 |
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| author | Rebecca J. Dodd Judith E. Allen Anthony J. Day |
| author_facet | Rebecca J. Dodd Judith E. Allen Anthony J. Day |
| author_sort | Rebecca J. Dodd |
| collection | DOAJ |
| description | ABSTRACT The polysaccharide hyaluronan (HA) is an important component of lung extracellular matrix that increases following infection with influenza or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hellman et al. (U. Hellman, E. Rosendal, J. Lehrstrand, J. Henriksson, et al., mBio 15:e01303-24, https://doi.org/10.1128/mbio.01303-24) show that fragmented HA accumulates in the lungs of coronavirus disease 2019 (COVID-19) patients, with systemic levels of HA being associated with reduced lung function 3–6 months after infection. This study provides novel insights into HA’s role in COVID-19 pathology and its potential utility as a biomarker for disease severity. However, much remains to be understood about the lung HA matrix in COVID-19 and how it compares to other lung conditions. In particular, the role of HA-binding proteins in organizing HA into a crosslinked network is yet to be fully determined at a molecular level. This knowledge is crucial in understanding the inter-relationships between the structure of the HA matrix and the regulation of the immune response, and thus our ability to target HA therapeutically for improved outcomes in COVID-19. |
| format | Article |
| id | doaj-art-176c902dc3b64741958a5cd467427e0d |
| institution | Kabale University |
| issn | 2150-7511 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-176c902dc3b64741958a5cd467427e0d2024-12-11T14:02:31ZengAmerican Society for MicrobiologymBio2150-75112024-12-01151210.1128/mbio.02609-24Hyaluronan in COVID-19: a matrix for understanding lung diseaseRebecca J. Dodd0Judith E. Allen1Anthony J. Day2Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Academic Health Science Centre, Manchester, United KingdomWellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Academic Health Science Centre, Manchester, United KingdomWellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Academic Health Science Centre, Manchester, United KingdomABSTRACT The polysaccharide hyaluronan (HA) is an important component of lung extracellular matrix that increases following infection with influenza or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hellman et al. (U. Hellman, E. Rosendal, J. Lehrstrand, J. Henriksson, et al., mBio 15:e01303-24, https://doi.org/10.1128/mbio.01303-24) show that fragmented HA accumulates in the lungs of coronavirus disease 2019 (COVID-19) patients, with systemic levels of HA being associated with reduced lung function 3–6 months after infection. This study provides novel insights into HA’s role in COVID-19 pathology and its potential utility as a biomarker for disease severity. However, much remains to be understood about the lung HA matrix in COVID-19 and how it compares to other lung conditions. In particular, the role of HA-binding proteins in organizing HA into a crosslinked network is yet to be fully determined at a molecular level. This knowledge is crucial in understanding the inter-relationships between the structure of the HA matrix and the regulation of the immune response, and thus our ability to target HA therapeutically for improved outcomes in COVID-19.https://journals.asm.org/doi/10.1128/mbio.02609-24lung infectionextracellular matrixhyaluronan |
| spellingShingle | Rebecca J. Dodd Judith E. Allen Anthony J. Day Hyaluronan in COVID-19: a matrix for understanding lung disease mBio lung infection extracellular matrix hyaluronan |
| title | Hyaluronan in COVID-19: a matrix for understanding lung disease |
| title_full | Hyaluronan in COVID-19: a matrix for understanding lung disease |
| title_fullStr | Hyaluronan in COVID-19: a matrix for understanding lung disease |
| title_full_unstemmed | Hyaluronan in COVID-19: a matrix for understanding lung disease |
| title_short | Hyaluronan in COVID-19: a matrix for understanding lung disease |
| title_sort | hyaluronan in covid 19 a matrix for understanding lung disease |
| topic | lung infection extracellular matrix hyaluronan |
| url | https://journals.asm.org/doi/10.1128/mbio.02609-24 |
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