Causal Effects of Sleep Quality on Primary Headache and the Mediation via Gut Microbiota: A Mendelian Randomization Study
ABSTRACT Background Previous studies have shown that sleep quality plays an essential role in primary headaches to varying degrees. However, it is unclear precisely whether gut microbiota plays a critical role in mediating changes in sleep quality and affecting primary headaches. Methods We utilized...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70129 |
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| author | Huanghong Zhao Dongsheng Guan Zhen Ma Minghui Yang Ning Dong Jian Guo |
| author_facet | Huanghong Zhao Dongsheng Guan Zhen Ma Minghui Yang Ning Dong Jian Guo |
| author_sort | Huanghong Zhao |
| collection | DOAJ |
| description | ABSTRACT Background Previous studies have shown that sleep quality plays an essential role in primary headaches to varying degrees. However, it is unclear precisely whether gut microbiota plays a critical role in mediating changes in sleep quality and affecting primary headaches. Methods We utilized Mendelian randomization (MR) to examine the causal relationships between sleep quality and primary headaches. The data encompass eight sleep traits (staying asleep during periods of anxiety, trouble falling asleep, daytime dozing, sleep apnea syndrome, oversleeping, undersleeping, snoring, and sleeplessness). The primary statistical method employed was inverse variance weighting. Eventually, we explored whether gut microbiota mediate the relationship between sleep quality and primary headaches. Results Our study found that a genetic predisposition to poor sleep quality increases the risk of primary headaches. Two‐step MR analysis revealed that the genus Coprococcus1 mediates the causal relationship between trouble falling asleep and cluster headaches, with a mediating effect of 23.6%. These findings could inform targeted interventions and treatments for primary headaches. Conclusion This study suggests that trouble falling asleep increases the incidence of cluster headaches mediated by gut microbiota. It highlights the crucial impact of sleep quality on primary headaches. |
| format | Article |
| id | doaj-art-175d1ae7b9194f79adc2496b126d02f9 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-175d1ae7b9194f79adc2496b126d02f92024-11-28T14:22:33ZengWileyBrain and Behavior2162-32792024-11-011411n/an/a10.1002/brb3.70129Causal Effects of Sleep Quality on Primary Headache and the Mediation via Gut Microbiota: A Mendelian Randomization StudyHuanghong Zhao0Dongsheng Guan1Zhen Ma2Minghui Yang3Ning Dong4Jian Guo5Department of Brain Disease Henan Provincial Hospital of Traditional Chinese Medicine Zhengzhou ChinaDepartment of Brain Disease Henan Provincial Hospital of Traditional Chinese Medicine Zhengzhou ChinaThe First Affiliated Hospital of Henan University of Traditional Chinese Medicine ZhengzhouChinaDepartment of Brain Disease Henan Provincial Hospital of Traditional Chinese Medicine Zhengzhou ChinaDepartment of Brain Disease Henan Provincial Hospital of Traditional Chinese Medicine Zhengzhou ChinaDepartment of Brain Disease Henan Provincial Hospital of Traditional Chinese Medicine Zhengzhou ChinaABSTRACT Background Previous studies have shown that sleep quality plays an essential role in primary headaches to varying degrees. However, it is unclear precisely whether gut microbiota plays a critical role in mediating changes in sleep quality and affecting primary headaches. Methods We utilized Mendelian randomization (MR) to examine the causal relationships between sleep quality and primary headaches. The data encompass eight sleep traits (staying asleep during periods of anxiety, trouble falling asleep, daytime dozing, sleep apnea syndrome, oversleeping, undersleeping, snoring, and sleeplessness). The primary statistical method employed was inverse variance weighting. Eventually, we explored whether gut microbiota mediate the relationship between sleep quality and primary headaches. Results Our study found that a genetic predisposition to poor sleep quality increases the risk of primary headaches. Two‐step MR analysis revealed that the genus Coprococcus1 mediates the causal relationship between trouble falling asleep and cluster headaches, with a mediating effect of 23.6%. These findings could inform targeted interventions and treatments for primary headaches. Conclusion This study suggests that trouble falling asleep increases the incidence of cluster headaches mediated by gut microbiota. It highlights the crucial impact of sleep quality on primary headaches.https://doi.org/10.1002/brb3.70129gut microbiotamediation analysisMendelian randomizationprimary headachessleep quality |
| spellingShingle | Huanghong Zhao Dongsheng Guan Zhen Ma Minghui Yang Ning Dong Jian Guo Causal Effects of Sleep Quality on Primary Headache and the Mediation via Gut Microbiota: A Mendelian Randomization Study Brain and Behavior gut microbiota mediation analysis Mendelian randomization primary headaches sleep quality |
| title | Causal Effects of Sleep Quality on Primary Headache and the Mediation via Gut Microbiota: A Mendelian Randomization Study |
| title_full | Causal Effects of Sleep Quality on Primary Headache and the Mediation via Gut Microbiota: A Mendelian Randomization Study |
| title_fullStr | Causal Effects of Sleep Quality on Primary Headache and the Mediation via Gut Microbiota: A Mendelian Randomization Study |
| title_full_unstemmed | Causal Effects of Sleep Quality on Primary Headache and the Mediation via Gut Microbiota: A Mendelian Randomization Study |
| title_short | Causal Effects of Sleep Quality on Primary Headache and the Mediation via Gut Microbiota: A Mendelian Randomization Study |
| title_sort | causal effects of sleep quality on primary headache and the mediation via gut microbiota a mendelian randomization study |
| topic | gut microbiota mediation analysis Mendelian randomization primary headaches sleep quality |
| url | https://doi.org/10.1002/brb3.70129 |
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